Mammalian antigen-presenting T cells and bi-specific T cells
AssigneeCity of Hope
InventorsLaurence Cooper, Michael Jensen
Life of this patent
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Abstract
The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to viral specific T cells that express chimeric anti-tumor receptors. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.
Claims15
A bi-specific T cell which expresses and bears on its surface a viral antigen T cell receptor and cancer antigen-specific chimeric receptor.
A method for vaccinating patients with a desired antigen by administering T cells genetically modified to express the desired antigen.
A method of eliminating bi-specific T cells in vivo by withdrawing administration of the viral antigen recognized by the bi-specific T cell or with-holding viral antigen recognized by the bi-specific T cell.
Dependencies are inferred from the claim text.