West Nile vaccine
AssigneeWyeth
InventorHsien-Jue Chu
Life of this patent
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Abstract
The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
Claims29
A vaccine composition which comprises:
- an effective immunizing amount of an inactivated subunit West Nile virus;
- an immunogenically stimulating amount of a metabolizable oil;
- and a pharmacologically acceptable carrier.
(canceled)
9-20. (canceled)
A vaccine composition, comprising:
- a) at least about 1×104 TCID50 and up to about 1×109 TCID50 per unit dose of inactivated subunit West Nile virus;
- and
- b) about 4% to 10% vol/vol of a metabolizable oil adjuvant comprising about 1 to 3% polyoxyethylene-polyoxypropylene block copolymer, about 2 to 6% of squalane and about 0.1 to 0.5% of polyoxyethylene sorbitan monooleate.
A West Nile virus vaccine for equidae, comprising:
- a) at least about 1×106 TCID50 to about 1×108 TCID50 per unit dose of killed or inactivated subunit West Nile virus, and
- b) at least about 1% vol/vol of an adjuvant comprising at least one metabolizable oil and at least one wetting or dispersing agent.
A vaccine regimen for horses or other equidae, comprising two dosage units of killed or inactivated subunit West Nile virus, wherein each said dosage unit comprises about 0.5 to 5 milliliters of a composition containing at least about 5×107 TCID50 of said subunit virus and about 1 to 10% vol/vol of an adjuvant, said adjuvant comprising at least one metabolizable oil and at least two nonionic surfactants, and further wherein said dosage unit comprises a pharmacologically acceptable carrier.
37-41. (canceled)
Dependencies are inferred from the claim text.