Yeast-dendritic cell vaccines and uses thereof
AssigneesThe Regents of the University of Colorado, GlobeImmune, Inc.
InventorsRichard Duke, Donald Bellgrau, Alex Franzusoff, Cara Wilson
Life of this patent
Estimating the term…
Abstract
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.
Claims21
1-28. (canceled)
A method to elicit an antigen-specific immune response in a mammal, the method comprising administering to the mammal an immunogenic composition comprising:
- a) a yeast vehicle selected from the group consisting of:
- a whole yeast, a yeast spheroplast, a yeast cytoplast, a yeast ghost, and a subcellular yeast particle;
- and,
- b) at least one antigen that is heterologous to the yeast vehicle and that is not expressed by or loaded into the yeast vehicle.
An immunogenic composition, comprising:
- a) a yeast vehicle selected from the group consisting of:
- a whole yeast, a yeast splieroplast, a yeast cytoplast, a yeast ghost, and a subcellular yeast particle;
- and
- b) at least one antigen that is heterologous to the yeast vehicle and that is not expressed by or loaded into the yeast vehicle;
- wherein the composition is formulated for parenteral delivery, mucosal delivery, aerosol delivery, or oral delivery.
A method to produce an immunogenic composition, comprising combining:
- a) a yeast vehicle selected from the group consisting of:
- a whole yeast, a yeast spheroplast, a yeast cytoplast, a yeast ghost, and a subcellular yeast particle;
- and,
- b) at least one antigen that is heterologous to the yeast vehicle and that is not expressed by or loaded into the yeast vehicle.
Dependencies are inferred from the claim text.