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US 2007/0166317 A1Published application
Microparticles
OwnerGavin Halbertinventor
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Abstract
The present invention relates to microparticles formed from polymer materials and comprising a peptide anchored thereto for binding to a cell surface receptor, for delivering agents to cells and to a method of making such microparticles.
Claims18
A microparticle for use in delivering an agent or agents to a cell, the microparticle comprising:
- a) a polymer shell;
- b) an agent or agents for delivery to a cell;
- and
- c) a peptide component comprising a hydrophobic moiety wherein the hydrophobic moiety is capable of anchoring the peptide to the polymer shell and the peptide is intended to target the microparticle to a receptor on the surface of the cell.
1 more element
16-17. (canceled)
A method of forming a peptide modified polymer microparticle, which comprises:
- a) forming a non-aqueous solution comprising a polymer, and an agent or agents;
- b) forming a dispersion of an aqueous liquid in the non-aqueous solution;
- sonicating the dispersion so as to form microparticles;
- and
- c) evaporating off the non-aqueous solution so as to leave an aqueous liquid comprising the microparticles, wherein the hydrophobically modified peptide may be included in the initial non-aqueous solution, or may be added to the aqueous liquid after microparticle formation.
2 more elements
Dependencies are inferred from the claim text.