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AssigneesThe Government of the United States of America as represented by the Secretary of the, Department of Health and Human Services
InventorsShousun Szu, Zuzana Kossaczka, John Robbins
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The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present disclosure also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.
A conjugate molecule, comprising the capsular polysaccharide of Vibrio cholerae O139, covalently bound to a carrier protein, wherein the carrier protein is a mutated diphtheria toxin, wherein the conjugate elicits serum antibodies vibriocidal to Vibrio cholerae O139.
Dependencies are inferred from the claim text.