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US 2007/0166309 A1Published application
Optimized anti-cd30 antibodies
AssigneeXencor, Inc.
InventorsGregory Lazar, John Desjarlais, Philip Hammond, David Carmichael, Bao-lu Chen, Seung Chu, Sher Karki
Life of this patent
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Abstract
An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.
Claims30
1-24. (canceled)
An anti-CD30 antibody comprising an engineered glycoform comprising an altered level of fucosylation as compared to a parent Fc polypeptide.
Dependencies are inferred from the claim text.