US 2007/0166308 A1 · Antibodies to MAdCAM

Abstract

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.

Claims53

Dependent claims

A human monoclonal antibody or an antigen-binding portion thereof that specifically binds to Mucosal Adressin Cell Adhesion Molecule (MAdCAM).

A monoclonal antibody that specifically binds MAdCAM, wherein the antibody is selected from the group consisting of:

(a) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
2 and SEQ ID NO:
4, without the signal sequences;
(b) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
6 and SEQ ID NO:
8, without the signal sequences;
(c) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
10 and SEQ ID NO:
12, without the signal sequences;
(d) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
14 and SEQ ID NO:
16, without the signal sequences;
(e) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
18 and SEQ ID NO:
20, without the signal sequences;
(f) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
22 and SEQ ID NO:
24, without the signal sequences;
(g) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
26 and SEQ ID NO:
28, without the signal sequences;
(h) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
30 and SEQ ID NO:
32, without the signal sequences;
(i) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
34 and SEQ ID NO:
36, without the signal sequences;
(j) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
38 and SEQ ID NO:
40, without the signal sequences;
(k) an antibody comprising the amino acid sequences set forth in SEQ ED NO:
42 and SEQ ID NO:
44, without the signal sequences;
(l) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
46 and SEQ ID NO:
48, without the signal sequences;
(m) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
52 and SEQ ID NO:
54, without the signal sequences;
(n) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
56 and SEQ ID NO:
58, without the signal sequences;
(o) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
60 and SEQ ID NO:
62, without the signal sequences;
(p) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
64 and SEQ ID NO:
66, without the signal sequences;
and
(q) an antibody comprising the amino acid sequences set forth in SEQ ID NO:
42 and SEQ ID NO:
68, without the signal sequences.

49 more elements

A monoclonal antibody or an antigen-binding portion thereof that specifically binds MAdCAM, wherein:

(a) the heavy chain comprises the heavy chain CDR1, CDR2 and CDR3 amino acid sequences of a reference antibody selected from the group consisting of:
1.7.2, 1.8.2, 6.14.2, 6.22.2, 6.34.2, 6.67.1, 6.73.2, 6.77.1, 7.16.6, 7.20.5, 7.26.4, 9.8.2, 6.22.2-mod, 6.34.2-mod, 6.67.1-mod, 6.77.1-mod and 7.26.4-mod
(b) the light chain comprises the light chain CDR1, CDR2 and CDR3 amino acid sequences of a reference antibody selected from the group consisting of:
1.7.2, 1.8.2, 6.14.2, 6.22.2, 6.34.2, 6.67.1, 6.73.2, 6.77.1, 7.16.6, 7.20.5, 7.26.4, 9.8.2, 6.22.2-mod, 6.34.2-mod, 6.67.1-mod, 6.77.1-mod and 7.26.4-mod
(c) the antibody comprises a heavy chain of (a) and a light chain of (b);
and
(d) the antibody of (c) wherein the heavy chain and light chain CDR amino acid sequences are selected from the same reference antibody.

4 more elements

Dependencies are inferred from the claim text.

Antibodies to MAdCAM

Life of this patent

Antibodies to MAdCAM

Life of this patent

Abstract

Claims53