Formulations for the rectal administration of thrombolytically-active agents
AssigneeCentro de Ingenieria Genetica y Biotechnologia
InventorsMaria Marrero Miragaya, Ann Barreto, Lisette Chavez, Eduardo Diaz, Beatriz Cabrera, Karelia Diaz, Milesa Sarmiento Mayea, Luciano Hermandez Marrero, Beatriz Santos
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Abstract
Pharmaceutical formulations in suppository form, containing thrombolytic agents, which are able to penetrate rectal mucous, for the treatment of acute hemorrhoid diseases and/or diseases of thrombotic origin.
Claims6
1-20. (canceled)
The use of peptides and proteins with thrombolytic action for the manufacture of a medicament for treating occlusive peripheral vascular disease, hemorrhoid disease, in particular the occlusion of hemorrhoidal vessels and disorders associated with these diseases in a subject, by rectal route.
The use according to claim 1 wherein the medicament is a rectal formulation.
The use according to claim 1 wherein the medicament comprises peptides and proteins where at least one of the components is a clot-lytic agent.
The use according to claim 1 wherein the medicament comprises recombinant streptokinase and pharmacologically acceptable diluent carrier or excipient for rectal route.
The use according to claim 4 wherein the medicament comprises recombinant streptokinase in a concentration from 50,000-1,500,000 Ul/g.
Dependencies are inferred from the claim text.