Formulation to improve survival of transplanted cells
AssigneeUniversity of Washington
InventorsCharles Murry, Michael Laflamme
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Abstract
The survival of cells during transplantation is enhanced. Cells to be transplanted are administered in a formulation that provides two ore more survival enhancing factors. Optionally, prior to administration, the cells are cultured in the presence of factors that enhance survival, and may be heat shocked prior to transplantation.
Claims11
A method for the transplantation of mammalian cells, the method comprising:
- administering a cellular composition comprising said mammalian cells in a fluid suspension comprising two or more survival enhancing factors.
A cellular composition comprising cardiomyocytes in a fluid suspension of solubilized basement membrane and at least one agent chosen from an immunosuppressive agent, a pan-caspase inhibitor, an anti-apoptotic agent, IGF-1, and a KATP channel opening agent;
- and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.