Compositions and methods for the treatment of hemophilia a

A method of treating hemophilia in a patient in need thereof, comprising:

• a) providing a vector comprising a nucleic acid sequence encoding a biologically active recombinant human factor VIII (FVIII), operably linked to expression control elements;
• and
• b) administering said vector to said patient under conditions that result in the expression of a modified human FVIII protein at a level that provides a therapeutic effect in said patient.

(canceled)

(canceled)