Polymeric reagents comprising a ketone or a related functional group
AssigneeNektar Therapeutics
InventorsSamuel McManus, Antoni Kozlowski, Xiaoming Shen, Daniel Cook
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Abstract
Polymeric reagents comprising a polymer attached, either directly or through one or more atoms, to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate, dithiohydrate, hemiketal, monothiohemiketal, dithiohemiketal, ketal, or dithioketal are provided. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
Claims10
A polymer-active agent conjugate comprising a covalent bond between a nitrogen atom of an active agent to a secondary carbon atom, wherein the secondary carbon atom is attached, either directly or through one or more atoms, to a water-soluble polymer segment
Dependencies are inferred from the claim text.