Methods and probes for identifying vulnerable plaque
OwnerRamtin Agahinventor
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Abstract
The present application discloses methods for detecting and localizing injuries in the vascular system of a subject, and in particular provides methods for detecting vulnerable or unstable plaques using oligo-deoxynucleotides (ODNs).
Claims9
A method for detection of vascular disease in a subject, comprising the steps of:
- (a) introducing into said subject an amount sufficient for later detection of a synthetic oligo-deoxynucleotide (ODN) having an affinity for, and a propensity to accumulate at, a site of vascular disease;
- (b) allowing said ODN to circulate within said vascular system, for a time sufficient to allow at least a portion of said ODN to accumulate at said site;
- and
- (c) detecting the accumulated ODN in the vascular system.
A diagnostic ODN selected from the group consisting of 5′-AGCTG CACTGATTGC CCTTTACCTC CT-3′ (SEQ ID NO:4) (ODN-1), 5′-GGGAATG CAATAGATGA AATCT-3′ (SEQ ID NO:5) (ODN-2), 5′-CAGTGGG GTACAATTTG TGACG ODN-3′ (SEQ ID NO:6) (ODN-3), 5′-TTGGAATAGTGACAGCTCA-3′ (SEQ ID NO:1) (ODN-4), 5′-CTGACCAAAGACTTAATGA3′ (SEQ ID NO:2) (ODN-5) and 5′-AACATCACCTTCATTCAAG-3′ (SEQ ID NO:3) (ODN-6).
Dependencies are inferred from the claim text.