Apparatus and method for ion calibrant introduction
AssigneeAgilent Technologies, Inc.
InventorsJean-Luc Truche, Jian Bai, Paul Goodley
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Abstract
The present invention relates to an apparatus and method for introducing calibrant ions into a conduit, ion source and/or mass spectrometry system.
Claims23
An ion source, comprising:
- (a) an ionization device for producing ions in an ionization region;
- (b) a collecting conduit downstream from the ionization device for collecting ions;
- (c) a conduit for introducing calibrants and heated gas into the ionization region;
- and
- (d) a discharge electrode adjacent to the conduit for creating ionization of calibrants within the heated gas.
A mass spectrometry system for introducing calibrant ions into an ionization region, comprising:
- (a) an ion source, comprising:
- (i) an ionization device for producing ions in an ionization region;
- (ii) a collecting conduit downstream from the ionization device for collecting ions;
- (iii) a conduit for introducing calibrants and heated gas into the ionization region;
- and
- (iv) a discharge electrode adjacent to the conduit for creating ionization of calibrants within the heated gas;
- and
- (b) a detector downstream from the ion source for detecting ions.
A conduit for providing a heated gas and calibrant ions to analyte ions produced by a matrix based ion source and discharged to an ionization region adjacent to a collecting capillary.
A method of generating calibration ions for an ion source, comprising:
- (a) producing sample ions using an ionization device,
- (b) applying a heated gas to the sample ions;
- (c) introducing a calibrant into the heated gas;
- and
- (d) ionizing the calibrant using an electrode to generate calibration ions.
A method of generating calibration ions in a heated gas for introduction into sample ions, comprising:
- (a) providing a calibrant in a heated gas;
- (b) ionizing the calibrant in the heated gas using an electrode to generate calibration ions;
- and
- (c) introducing the calibrations ions and heated gas into the sample ions.
Dependencies are inferred from the claim text.