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US 2007/0163663 A1Published application
Fluid logic device
AssigneeProtasis Corporation
InventorsDavid Strand, Daniel Leatzow
Life of this patent
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Abstract
Novel fluid logic devices are disclosed. Certain examples of the fluid logic devices include two or more fluid logic gates that are each operative to select and/or direct analytes in a sample into one or more fluid flow channels in communication with the fluid logic gates. The fluid logic device can be part of a larger system, such as a chromatography system, or can be stand-alone device.
Claims31
A fluid logic device comprising:
- a first flow channel;
- a first bulk fluid flow gate in fluid communication with the first flow channel;
- and
- a second bulk fluid flow gate in communication with the first bulk fluid flow gate, the first bulk fluid flow gate and the second bulk fluid flow gate each comprising
- a first fluid flow chamber;
- and
- at least one electrode operative when energized to generate an electric field in the first fluid flow chamber;
- wherein the first fluid flow chamber comprises
- a first fluid inlet port configured to receive bulk fluid flow into the first fluid flow chamber,
- a first fluid outlet port configured to pass bulk fluid from the first chamber,
- a second fluid inlet port configured to receive sample fluid flow into the first fluid flow chamber at a location between the first fluid inlet port and the first fluid outlet port, and
- a second fluid outlet port configured to pass fluid from the first fluid flow chamber, the first fluid outlet port and the second fluid outlet port being on opposite sides of the first fluid inlet port,
- each of the bulk fluid flow gates when receiving a bulk fluid flow into the first fluid flow chamber via the first fluid inlet port and simultaneously a sample fluid flow into the first fluid flow chamber via the second inlet port, presenting greater hydrodynamic resistance to passing fluid from the first fluid flow chamber via the second outlet port than via the first fluid outlet port.
10 more elements
A fluid logic device comprising:
- a first flow channel;
- a first bulk fluid flow gate in fluid communication with the first flow channel;
- and
- a second bulk fluid flow gate in communication with the first bulk fluid flow gate, the first bulk fluid flow gate and the second bulk fluid flow gate each comprising
- a first entry port for introducing bulk fluid into the first chamber,
- a first exit port for exiting of bulk fluid from the first chamber,
- a second entry port positioned between the first entry port and the first exit port, the second entry port for introducing sample into the first chamber, and
- a second exit port, in which bulk fluid introduced through the first entry port experiences substantially greater hydrodynamic resistance at the first exit port than at the second exit port;
- and means for generating an electric field in electrical communication with the first bulk fluid flow gate and means for generating an electric field in electrical communication with the second bulk fluid flow gate.
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A method comprising:
- providing a fluid logic device, the fluid logic device comprising:
- a first a first flow channel;
- a first bulk fluid flow gate in fluid communication with the first flow channel;
- and
- a second bulk fluid flow gate in communication with the first bulk fluid flow gate, the first bulk fluid flow gate and the second bulk fluid flow gate each comprising
- a first entry port for introducing bulk fluid into the first chamber,
- a first exit port for exiting of bulk fluid from the first chamber,
- a second entry port positioned between the first entry port and the first exit port, the second entry port for introducing sample into the first chamber, and
- a second exit port, in which bulk fluid introduced through the first entry port experiences substantially greater hydrodynamic resistance at the first exit port than at the second exit port,
- means for generating an electric field in electrical communication with the first bulk fluid flow gate and means for generating an electric field in electrical communication with the second bulk fluid flow gate;
- introducing sample comprising charged analyte into the fluid logic device through the second entry port of the first bulk fluid flow gate;
- introducing bulk fluid flow into the first entry port of the first bulk fluid flow gate;
- applying an electric field to the first bulk fluid flow gate and the second bulk fluid flow gate to separate the charged analyte in the sample.
10 more elements
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A fluid logic device comprising:
- a first flow channel;
- a first fluid flow gate in fluid communication with the first flow channel;
- and
- a second fluid flow gate in communication with the first fluid flow gate, the first fluid flow gate and the second fluid flow gate each comprising
- a micro-scale first fluid flow chamber;
- and
- at least one electrode operative when energized to generate an electric field in the micro-scale first fluid flow chamber;
- wherein the micro-scale first fluid flow chamber comprises
- a first fluid inlet port configured to receive fluid flow into the micro-scale first fluid flow chamber,
- a first fluid outlet port configured to pass fluid from the micro-scale first chamber, and
- a second fluid outlet port configured to pass fluid from the micro-scale first fluid flow chamber.
8 more elements
A fluid logic device comprising:
- a first flow channel;
- a first fluid flow gate in fluid communication with the first flow channel;
- and
- a second fluid flow gate in communication with the first fluid flow gate, the first fluid flow gate and the second fluid flow gate each comprising
- a first fluid flow chamber;
- and
- at least one electrode operative when energized to
- generate an electric field in the first fluid flow chamber;
- wherein the first fluid flow chamber comprises
- a first fluid inlet port configured to receive fluid flow into the first fluid flow chamber,
- a first fluid outlet port configured to pass fluid from the first chamber, and
- a second fluid outlet port configured to pass fluid from the first fluid flow chamber,
- the fluid flow gate when receiving a fluid flow into the first fluid flow chamber presenting greater hydrodynamic resistance to passing fluid from the first fluid flow chamber via the second outlet port than via the first fluid outlet port.
10 more elements
Dependencies are inferred from the claim text.