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US 2007/0163610 A1Published application
Formulation and Use and Manufacture Thereof
AssigneePharmacia Corporation
InventorsKatarina Lindell, Bengt Bosson, Gunnar Bergengren, Anette Schluter
Life of this patent
Estimating the term…
Abstract
This invention relates to a liquid pharmaceutical formulation for delivering nicotine to a subject. This invention also relates to a method and a system for delivering nicotine as well as manufacturing and use of said liquid pharmaceutical formulation.
Claims20
A method for delivering nicotine to a subject, the method comprising the steps of:
- (a) administering a liquid pharmaceutical composition comprising nicotine into the oral cavity of a subject by spraying, dropping or pipetting thereby providing oral transmucosal delivery of nicotine to the subject without chewing or sucking, said composition having an alkaline pH and further comprising one or more buffers in an amount sufficient to transiently increase the pH of liquid in the oral cavity of said subject by about 0.3 to about 4 pH units;
- and
- (b) allowing the nicotine to be systematically absorbed by buccal uptake.
A method for obtaining reduction of the urge to use tobacco containing material in a subject, the method comprising the steps of:
- (a) replacing some or all of the tobacco containing material with a liquid pharmaceutical composition comprising nicotine, said composition having an alkaline pH and further comprising one or more buffers in an amount sufficient to transiently increase the pH of liquid in the oral cavity of said subject by about 0.3 to about 4 pH units;
- (b) administering the liquid pharmaceutical composition into the oral cavity of a subject by spraying, dropping or pipetting thereby providing oral transmucosal delivery of nicotine to said subject without chewing or sucking;
- and
- (c) allowing the nicotine to be systematically absorbed by the subject.
1 more element
A method for treating a disease, the method comprising the steps of:
- (a) administering a liquid pharmaceutical composition comprising nicotine into the oral cavity of a subject by spraying, dropping or pipetting thereby providing oral transmucosal delivery of nicotine to the subject without chewing or sucking, said composition having an alkaline pH and further comprising one or more buffers in an amount sufficient to transiently increase the pH of liquid in the oral cavity of said subject by about 0.3 to about 4 pH units;
- and
- (b) allowing the nicotine to be systematically absorbed by buccal uptake, wherein the disease is selected from the group consisting of addiction to tobacco or nicotine, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerative colitis, and weight control.
Dependencies are inferred from the claim text.