Sugar chain-cleaving agent
AssigneeSeikagaku Corporation
InventorsHisashi Narimatsu, Koji Kimata, Toshikazu Yada
Life of this patent
Estimating the term…
Abstract
A sugar chain-cleaving agent, which comprises a protein having activity of degrading chondroitin and/or chondroitin sulfate; a medicament which comprises the sugar chain-cleaving agent as an active ingredient; a method for specifically cleaving a sugar chain, which comprises reacting the protein with chondroitin and/or chondroitin sulfate; and a method for specifically producing a sugar chain of which molecular weight is decreased, which reacting the protein with chondroitin and/or chondroitin sulfate.
Claims18
A sugar chain-cleaving agent, which comprises the following protein (a) or (b) as an active ingredient:
- (a) a protein which comprises the amino acid sequence represented by amino acid numbers 37 to 532 in SEQ ID NO:2;
- (b) a protein which comprises an amino acid sequence having addition, deletion, substitution, insertion and/or transposition of one or several amino acids in the amino acid sequence represented by amino acid numbers 37 to 532 in SEQ ID NO:2, and has activity of degrading chondroitin and/or chondroitin sulfate.
(canceled)
A method for specifically cleaving a sugar chain, which comprises reacting the following protein (a) or (b) with chondroitin and/or chondroitin sulfate:
- (a) a protein which comprises the amino acid sequence represented by amino acid numbers 37 to 532 in SEQ ID NO:2;
- (b) a protein which comprises an amino acid sequence having addition, deletion, substitution, insertion and/or transposition of one or several amino acids in the amino acid sequence represented by amino acid numbers 37 to 532 in SEQ ID NO:2, and has activity of degrading chondroitin and/or chondroitin sulfate.
A method for specifically producing a sugar chain of which molecular weight is decreased, which reacting the following protein (a) or (b) with chondroitin and/or chondroitin sulfate:
- (a) a protein which comprises the amino acid sequence represented by amino acid numbers 37 to 532 in SEQ ID NO:2;
- (b) a protein which comprises an amino acid sequence having addition, deletion, substitution, insertion and/or transposition of one or several amino acids in the amino acid sequence represented by amino acid numbers 37 to 532 in SEQ ID NO:2, and has activity of degrading chondroitin and/or chondroitin sulfate.
Dependencies are inferred from the claim text.