Apoptosis promoters

A compound having formula (I),

• or a therapeutically acceptable salt thereof, wherein
• A1 is A2, A3, A4 or A5;
• A2 is C1-C5-alkyl, C2-C5-alkenyl or C2-C5-alkynyl, each of which is substituted with R1 and further unsubstituted or substituted with one or two of independently selected OH, O(CH3), NH2, NH(CH3) or N(CH3)2;
• A3 is OR1, NHR1, N(RA)R1, SR1, S(O)R1, SO2R1, C(O)R1, C(S)R1, L1OR1, L1NHR1, L1N(RA)R1, L1SR1, L1S(O)R1, L1SO2R1, L1C(O)R1, L1C(S)R1, OL1R1, NHL1R1, N(RA)L1R1, SL1R1, S(O)L1R1, SO2L1R1, C(O)L1R1 or C(S)L1R1, wherein L1 C1-C4-alkylene or C3-C4-alkenylene and RA is alkyl;
• A4 is OC(O)R1, C(O)OR1, SC(O)R1, C(S)OR1, NHC(O)R1, C(O)NHR1, NHSO2R1, SO2NHR1, N(RA)C(O)R1, C(O)N(RA)R1, N(RA)SO2R1, SO2N(RA)R1, L2OC(O)R1, L2C(O)OR1, L2SC(O)R1, L2C(S)OR1, L2NHC(O)R1, L2C(O)NHR1, L2NHSO2R1, L2SO2NHR1, L2N(RA)C(O)R1, L2C(O)N(RA)R1, L2N(RA)SO2R1, L2SO2N(RA)R1, OC(O)L2R1, C(O)OL2R1, SC(O)L2R1, C(S)OL2R1, NHC(O)L2R1, C(O)NHL2R1, NHSO2L2R1, SO2NHL2R1, N(RA)C(O)L2R1, C(O)N(RA)L2R1, N(RA)SO2L2R1, SO2N(RA)L2R1, wherein L2 is C1-C3-alkylene or C2-C3-alkenylene;
• A5 is NHC(O)NHR1, NHSO2NHR1, N(RA)C(O)N(RA)R1, N(RA)SO2N(RA)R1, L3NHC(O)NHR1, L3NHSO2NHR1, L3N(RA)C(O)N(RA)R1, L3N(RA)SO2N(RA)R1, NHC(O)NHL3R1, NHSO2NHL3R1, N(RA)C(O)N(RA)L3R1, N(RA)SO2N(RA)L3R1, wherein L3 is C1-C2-alkylene;
• R1 is R2, OR2, NHR2, N(R2)2, SR2, S(O)R2, SO2R2, NHSO2R2, SO2NHR2, R3, OR3, NHR3N(R2)2, SR3, S(O)R3, SO2R3, NHSO2R3, SO2NHR3, R4, OR4, NHR4, N(R4)2, SO2NHR4, SR4, S(O)R4, SO2R4NHSO2R4 or SO2NHR4;
• R2 is phenyl which is unfused or fused with benzene, heteroarene or R2A, wherein R2A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R3 is heteroaryl which is unfused or fused with benzene, heteroarene or R3A, wherein R3A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R4 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R4A, wherein R4A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• B1 is phenyl substituted with one or two of independently selected F, Br, Cl or I;
• C1 is C2 or C3;
• C2 is CN, NO2, C(O)OH, F, Cl, Br, I, CF3, OCF3, CF2CF3, OCF2CF3, R8, OR8, C(O)R8, C(O)OR8, SR8, NH2, NHR8, N(R8)2, NHC(O)R8, C(O)NH2, C(O)NHR8, C(O)N(R8)2, NHS(O)R8 or NHSO2R8;
• C3 is S(O)R14, SO2R14, S(O)R15, SO2R15, S(O)R16 or SO2R16;
• R8 is R9, R10, R11 or R12;
• R9 is phenyl which is unfused or fused with benzene, heteroarene or R9A, wherein R9A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R10 is heteroaryl which is unfused or fused with benzene, heteroarene or R10A, wherein R10A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R11 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R11A, wherein R11A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R12 is alkyl, alkenyl or alkynyl, each of which us unsubstituted or substituted with R13;
• R13 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl;
• R14 is perhaloalkyl or perhaloalkenyl;
• R15 is C1-alkyl(methyl) or C2-alkenyl(vinyl), each of which is unsubstituted or substituted with one or two of independently selected F, Cl or Br;
• and
• R16 is C2-C6-alkyl, C3-C6-alkenyl or C4-C6-alkynyl, each of which is unsubstituted or substituted with one or two or three or four of independently selected F, Cl or Br;
• wherein R2, R3, R4, R2A, R3A, R4A, R9, R10, R11, R9A, R10A, R11A and R13 are independently unsubstituted or substituted with one or two or three or four or five of independently selected R17, OR17, SR17, S(O)R17, SO2R17, C(O)R17, CO(O)R17, OC(O)R17, OC(O)OR17, NH2, NHR17, N(R17)2, NHC(O)R17, C(O)NH2, C(O)NHR17, C(O)N(R17)2, C(O)NHOH, C(O)NHOR17, C(O)NHSO2R17, C(O)NR17, NHSO2R17, N(SO2R17)2, SO2NH2, SO2NHR17, SO2N(R17)2, C(O)H, C(O)OH, C(N)NH2, C(N)NHR17, C(N)N(R17)2, N═NR17, CNOH, CNOCH3, OH, (O), N3, NO2, CF3, CF2CF3, CF2Cl, SO2CF3, SO2CF2CF3, SO2CF2Cl, NHSO2CF3, NHSO2CF2CF3, OCF3, OCF2CF3, F, Cl, Br or I, wherein
• R17 is R18, R19, R20 or R21;
• R18 is phenyl which is unfused or fused with benzene, heteroarene or R18A, wherein R18A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R19 is heteroaryl which is unfused or fused with benzene, heteroarene or R19A, wherein R19A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R20 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R20A, wherein R20A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R21 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with one or two of independently selected alkyl, alkenyl, alkynyl, R22, OR22, NHR22N(Rc)R22, SR22, S(O)R22 or SO2R22;
• R22 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with, benzene, heteroarene or R22A, wherein R22A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• wherein the cyclic moieties represented by R18, R18A, R19, R19A, R20, R20A, R22 and R22A are independently unsubstituted or substituted with one or two or three or four or five of independently selected R23, OR23, NHR23, N(R23)2, SR23, S(O)R23 or SO2R23, CF3, CF2CF3, OH, NH2, NHCH3, N(CH3)2, N3, NO2, CF3, CF2CF3, NHSO2CF3, NHSO2CF2CF3, OCF3, OCF2CF3, F, Cl, Br or I;
• R23 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl or R24;
• R24 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl.