CB-1 modulating compounds and their use

A compound of formula (I):

• as a single isomer, a mixture of isomers, a racemic mixture of isomers, pharmaceutically acceptable salt, a solvate, metabolite or polymorph thereof, wherein:
• X is selected from the group consisting of O, S, S═O, SO2, NR1, NC≡N, NC(=Z)R1, NC(=Z)NR1aR1b, CR1aR1b, C═O, C═CR1aR1b, and SiR1aR1b;
• Y is —N(R2) or —C(R1R2);
• the symbol represents a single or double bond, where when is a double bond, R2 is absent;
• A is selected from the group consisting of C3-C12alkyl, C4-C12alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, (cycloalkyl)alkyl, (cycloalkenyl)alkyl, (cycloalkynyl)alkyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, (heteroalicyclyl)alkyl, halogen, —NR1aR1b, —N═CR1aR1b, sulfenyl, sulfinyl, sulfonyl, and —(CH2)0-4—C(=Z)—OR1, wherein any member of said group can be substituted or unsubstituted;
• provided that A cannot be a substituted or unsubstituted piperazine;
• B, C, D, E, F, G and I are separately selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heteroalicyclyl, (heteroalicyclyl)alkyl, halogen, hydroxyl, nitro, sulfenyl, sulfinyl, sulfonyl, haloalkyl, haloalkoxy, —CN, —C(=Z)R1, —C(=Z)OR1, —C(=Z)NR1aR1b, —C(=Z)N(R1)NR1aR1b, —C(=Z)N(R1)N(R1)C(=Z)R1, —C(R1)═NR1, —NR1aR1b, —N═CR1aR1b, —N(R1)—C(═Z)R1, —N(R1)—C(=Z)NR1aR1b, —S(O)NR1aR1b, —S(O)2NR1aR1b, —N(R1)—S(═O)R1, —N(R1)—S(=O)2R1, —OR1, —SR1, and —OC(=Z)R1, wherein any member of said group can be substituted or unsubstituted except for hydrogen;
• H is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heteroalicyclyl, (heteroalicyclyl)alkyl, halogen, hydroxyl, nitro, sulfenyl, sulfinyl, sulfonyl, haloalkyl, haloalkoxy, —CN, —C(=Z)R1, —C(═Z)OR1, —C(=Z)NR1aR1b, —C(=Z)N(R1)NR1aR1b, —C(═Z)N(R1)N(R1)C(=Z)R1, —C(R1)=NR1, —NR1aR1b, —N=CR1aR1b, —N(R1)—C(=Z)R1, —N(R1)—C(=Z)NR1aR1b, —S(O)NR1aR1b, —S(O)2NR1aR1b, —N(R1)—S(═O)R1, —N(R1)—S(═O)2R1, —OR1, —SR1, and —OC(=Z)R1, wherein any member of said group can be substituted or unsubstituted;
• with the proviso that H cannot be selected from the group consisting of —CF3, phenyl, —OS(O)2—CF3, methyl, —CN, halogen, and
• when A is a substituted or unsubstituted heteroalicyclyl containing at least one nitrogen or —NR1aR1b;
• with the proviso that H cannot be halogen when A is substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, halogen, and substituted or unsubstituted sulfenyl;
• X is —NR1, wherein R1 is hydrogen;
• and Y is —N(R2) , wherein is a double bond and R2 is absent;
• Z is O or S;
• R1, R1a and R1b are each independently selected from the group consisting of:
• hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalicyclyl, (heteroalicyclyl)alkyl, —(CH2)0-7—OR3, —(CH2)0-7—SR3, —(CH2)0-7—NR3aR3b, haloalkyl, —C(=Z)R3, —C(=Z)OR3and —C(=Z)NR3aR3b, wherein any member of said group can be substituted or unsubstituted except for hydrogen;
• or R1a and R1b can be taken together to form an unsubstituted or substituted heteroalicyclyl having 2 to 9 carbon atoms or an unsubstituted or substituted carbocyclyl having 3 to 9 carbon atoms;
• R2 is absent or is selected from the group consisting of:
• hydrogen, alkyl, alkenylt, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, and heteroalicyclyl, wherein any member of said group can be substituted or unsubstituted except for hydrogen;
• R3, R3a, and R3b are each independently selected from the group consisting of:
• hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, and (heteroalicyclyl)alkyl, wherein any member of said group can be substituted or unsubstituted except for hydrogen;
• with the proviso when X is O or —NR1, wherein R1 is methyl and Y is —N(R2) , wherein is a double bond and R2 is absent then H cannot be —C(=Z)OR1, wherein R1 is hydrogen, methyl, or ethyl;
• and
• with the proviso that when A is halogen, Y is —N(R2) , wherein is a double bond and R2 is absent, and X is S then F cannot be —S(O)2NR1aR1b, wherein R1a and R1 b are both hydrogen.