Sertraline acid addition salt, its preparation and its use in the preparation of sertraline hydrochloride form II
OwnerRamana Kintali, Johannes Ludescher +2inventors
InventorsRamana Kintali, Johannes Ludescher, Raji Nair, Sudhir Sawant
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Abstract
The present invention relates to novel acid addition salts of sertraline, their preparation and their use in the preparation of crystalline Form-II of Sertraline hydrochloride.
Claims7
An acid addition salt of sertraline wherein the acid is selected from phthalic acid, glutamic acid, adipic acid, salicylic acid, 4-methyl benzoic acid and 4-methoxy benzoic acid.
A process for preparing sertraline hydrochloride Form II which comprises (a) slurrying a sertraline acid salt wherein the acid is selected from phthalic acid, glutamic acid, adipic acid, salicylic acid, 4-methyl benzoic acid, 4-methoxy benzoic acid and (R)-mandelic acid in an organic solvent or organic solvent mixture at a temperature between ambient temperature and the boiling point of the solvent or solvent mixture, preferably between 25 and 80° C. (b) treating the slurry with a source of hydrochloric acid and (c) stirring the mixture obtained between ambient temperature and the boiling point of the solvent or solvent mixture for a period of time sufficient to effect the transformation to sertraline hydrochloride Form II.
Dependencies are inferred from the claim text.