# US 2007/0009900 A1 · Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics

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- Number: US 2007/0009900 A1
- Document ID: US20070009900A1
- Status: Published application
- Kind: A1
- Application number: 11/027,802
- Filed: 2004-12-30
- Published: 2007-01-11
- Earliest claimed: 1997-07-02
- Assignees: Aventis Pasteur Limited
- Inventors: Lynn Doucette-Stamm; David Bush; Qiandong Zeng; Timothy Opperman; Chad Houseweart
- Web page: https://patentgrep.com/patent/US20070009900A1

## CPC

- C07K 14/3156: {from Streptococcus pneumoniae (Pneumococcus) (Streptokinase C07K14/3153)}
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

## Claims

### Claim 1

An isolated nucleic acid encoding a S. pneumoniae polypeptide comprising SEQ ID NO: 5200.

### Claim 2

An isolated nucleic acid sequence comprising SEQ ID NO: 2539.

### Claim 3

An isolated nucleic acid sequence selected from the group consisting of:
a) SEQ ID NO: 2539,
b) a nucleic acid sequence having at least about 90% identity to SEQ ID NO: 2539,
c) a complement of SEQ ID NO: 2539,
d) a complement of a nucleic acid sequence having at least about 90% identity to SEQ ID NO: 2539, and
e) an RNA of a), b), c) or d), wherein U is substituted for T.

### Claim 4

An isolated nucleic acid comprising a nucleotide sequence that hybridizes under high stringency conditions to at least one member selected from the group consisting of:
a) SEQ ID NO: 2539,
b) a complement of SEQ ID NO: 2539,
c) an RNA of a) or b), wherein U is substituted for T.

### Claim 5

An isolated nucleic acid comprising at least about 40 consecutive nucleotides that hybridizes under high stringency conditions to SEQ ID NO: 2539.

### Claim 6 (depends on 1)

A recombinant expression vector comprising the nucleic acid of claim 1 operably linked to a transcription regulatory element.

### Claim 7 (depends on 2)

A recombinant expression vector comprising the nucleic acid of claim 2 operably linked to a transcription regulatory element.

### Claim 8 (depends on 6)

A cell comprising the recombinant expression vector of claim 6.

### Claim 9 (depends on 7)

A cell comprising the recombinant expression vector of claim 7.