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US 2007/0009489 A1Published application
Genetically modified tumor-targeted bacteria with reduced virulence
AssigneesVion Pharmaceuticals, Inc., Yale University
InventorsDavid Bermudes, Kenneth Low
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Abstract
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumors.
Claims22
A mutant Salmonella sp. comprising genetically modified msbB gene in which the mutant Salmonella is capable of targeting a solid tumor when administered in vivo.
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22-31. (canceled)
Dependencies are inferred from the claim text.