Analyte detection devices and methods with hematocrit/volume correction and feedback control

A method of measuring the content of analyte contained in a sample of body fluid, the method comprising:

• providing an assay pad comprising at least one chemical reagent;
• introducing a sample onto the assay pad;
• producing a detectable signal in the form of a reaction spot formed upon reaction of the at least one chemical reagent with the analyte;
• generating a signal based on light reflected off the assay pad;
• calculating at least one value indicative to one or more of:
• (i) the level of hematocrit contained in the sample;
• (ii) the volume of the sample applied to the assay pad;
• or
• (iii) imperfections present in the reaction spot;
• and
• calculating the concentration of analyte contained in the sample by factoring in the at least one value.

An arrangement for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement comprising:

• an assay pad comprising at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot formed upon reaction with the analyte;
• a light source;
• a detector array;
• a processor;
• a memory in communication with the processor;
• and
• at least one catalyst device constructed and arranged to be responsive to control signals.