# US 2006/0275350 A1 · Skin dressings containing oxidoreductase enzyme > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2006/0275350 A1 - Document ID: US20060275350A1 - Status: Published application - Kind: A1 - Application number: 10/557,998 - Filed: 2004-06-04 - Published: 2006-12-07 - Earliest claimed: 2003-06-09 - Assignees: Archimed LLP - Inventors: Paul Davis; Andrew Austin - Web page: https://patentgrep.com/patent/US20060275350A1 ## CPC - C12N 9/0004: {Oxidoreductases (1.)} - A61L 15/38: containing enzymes - A61P 17/00: Drugs for dermatological disorders - A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - C12N 9/96: Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates - C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A skin dressing comprises a first dressing component (16) carrying oxidoreductase enzyme in dried condition; and a second dressing component (18) carrying a source of water, such that when the first and second dressing components are placed in fluid communication with each other, water migrates from the second component towards the first comportent and acts to hydrate enzyme carried by the first component, at least at the surface of the first component. The dressing components are kept separate before use, e.g. being sealed in separate sterile, water-impervious packages such as laminated aluminium foil pouches. In use of the dressing, the second dressing component is located on the skin of a human or animal, e.g. over a wound to be treated or on a region of skin to be treated for cosmetic or therapeutic purposes such as for treatment of acne or other skin conditions. The first dressing component is placed on top of the second component in fluid communication therewith. In embodiments comprising only first and second dressing components, the first dressing component is placed in direct contact with the second dressing component. Water from the second component migrates towards the first comportent and acts to hydrate enzyme carried by the first component, at least at points of contact at the interface between the first and second components. Once hydrated, the oxidoreductase enzyme can immediately begin functioning in known manner with beneficial effects. ## Claims ### Claim 1 A skin dressing, comprising a first dressing component carrying oxidoreductase enzyme in dried condition; and a second dressing component carrying a source of water, such that when the first and second dressing components are placed in fluid communication with each other, water migrates from the second component towards the first component and acts to hydrate enzyme carried by the first component, at least at the surface of the first component. ### Claim 2 (depends on 1) A dressing according to claim 1, wherein the oxidoreductase enzyme comprises glucose oxidase. ### Claim 3 (depends on 1, 2) A dressing according to claim 1 or 2, including a source of substrate for the oxidoreductase enzyme. ### Claim 4 (depends on 3) A dressing according to claim 3, wherein the substrate is present in the second dressing component. ### Claim 5 (depends on 1) A dressing according to claim 1, including a supply of iodide ions. ### Claim 6 (depends on 1) A dressing according to claim 1, wherein the first component and second component are in the form of layers. ### Claim 7 (depends on 1) A dressing according to claim 1, wherein the first component comprises a support or carrier carrying enzyme. ### Claim 8 (depends on 7) A dressing according to claim 7, wherein the support or carrier comprises dried hydrogel material. ### Claim 9 (depends on 8) A dressing according to claim 8, wherein the hydrogel comprises hydrophilic polymer material. ### Claim 10 (depends on 9) A dressing according to claim 9, wherein the polymer comprises poly-2-acrylamido-2-methylpropane sulphonic acid and/or salts thereof. ### Claim 11 (depends on 9, 10) A dressing according to claim 9 or 10, wherein the hydrophilic polymer material is present at a concentration of at least 1%, preferably at least 2%, more preferably at least 5%, possibly at least 10%, by weight based on the total weight of the gel. ### Claim 12 (depends on 1) A dressing according to claim 1, wherein the second dressing component comprises a support or carrier carrying water. ### Claim 13 (depends on 12) A dressing according to claim 12, wherein the second component comprises a hydrated hydrogel. ### Claim 14 (depends on 13) A dressing according to claim 13, wherein the hydrated hydrogel comprises poly(−2-acrylamido-2-methylpropane sulphonic acid) and/or salts thereof. ### Claim 15 (depends on 14) A dressing according to claim 14, wherein the second component comprises a hydrated hydrogel comprising 20% by weight of poly(−2-acrylamido-2-methylpropane sulphonic acid) and/or a salt or salts. ### Claim 16 (depends on 13, 14, 15) A dressing according to claim 13, 14 or 15, wherein the hydrated hydrogel contains at least 30% by weight water. ### Claim 17 (depends on 15) A dressing according to claim 15, wherein the hydrated hydrogel contains about 60% by weight of water. ### Claim 18 (depends on 1) A dressing according to claim 1, wherein the first and second components both include gel supports comprising the same polymer. ### Claim 19 (depends on 18) A dressing according to claim 18, wherein the first and second components both include polymers that are functionally similar to each other in terms of hydration and water binding behaviour. ### Claim 20 (depends on 19) A dressing according to claim 19, wherein where the second component includes a support of poly(−2-acrylamido-2-methylpropane sulphonic acid) and/or a salt or salts thereof, and the first component includes polyvinyl alcohol. ### Claim 21 (depends on 1) A dressing according to claim 1, wherein the first component includes monomers that are identical or similar to monomers from which a polymeric support of the second component is formed. ### Claim 22 (depends on 1) A dressing according to claim 1, wherein the first dressing component includes one or more hydration enhancers. ### Claim 23 (depends on 22) A dressing according to claim 22, wherein the hydration enhancer is selected from dried sugars, especially sucrose and trehalose, glycerol and sorbitol. ### Claim 24 (depends on 1) A dressing according to claim 1, wherein the first component comprises a support of dried hydrogel formed from 10% by weight poly(−2-acrylamido-2-methylpropane sulphonic) acid and/or a salt or salts thereof, carrying enzyme, and the second component comprises a support of hydrated hydrogel comprising 20% by weight of poly(−2-acrylamido-2-methylpropane sulphonic acid) and/or a salt or salts thereof. ### Claim 25 (depends on 1) A dressing according to claim 1, wherein the first and/or second component includes one or more moisturiser materials. ### Claim 26 (depends on 1) A dressing according to claim 1, including a covering or outer layer for adhering the dressing to the skin of a human or animal subject. ### Claim 27 (depends on 1) A dressing according to claim 1, wherein the first and second components are separately sealed in respective packages prior to use.