Pentopyranosyl nucleic acid conjugates

A process for preparing a conjugate comprising the steps of:

• providing a pentopyranosyl nucleic acid, wherein the pentopyranosyl nucleic acid has at least two pentopyranosyl nucleotide subunits that are covalently linked between carbon 4 and carbon 2 of their respective pentopyranosyl rings, and wherein the pentopyranosyl nucleic acid further comprises an electrophilic reactive group;
• providing a biomolecule comprising a nucleophilic reactive group;
• and
• reacting the electrophilic reactive group of the pentopyranosyl nucleic acid and the nucleophilic reactive group of the biomolecule to form a covalent bond.

A process for preparing a conjugate comprising the steps of:

• providing a pentopyranosyl nucleic acid, wherein the pentopyranosyl nucleic acid has at least two pentopyranosyl nucleotide subunits that are covalently linked between carbon 4 and carbon 2 of their respective pentopyranosyl rings, and wherein the pentopyranosyl nucleic acid further comprises a nucleophilic reactive group;
• providing a biomolecule comprising an electrophilic reactive group;
• and
• reacting the electrophilic reactive group of the biomolecule and the nucleophilic reactive group of the pentopyranosyl nucleic acid to form a covalent bond.