Nucleic acids and proteins from Streptococcus pneumoniae
AssigneeMicrobial Technics Limited
InventorsRichard Le Page, Jeremy Wells, Sean Hanniffy, Philip Hansbro
Life of this patent
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Abstract
Novel proteins from Streptococcus pneumoniae are described, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.
Claims20
A Streptococcus pneumoniae protein or polypeptide having a sequence selected from those shown in table 1.
A Streptococcus pneumoniae protein or polypeptide having a sequence selected from those shown in table 2.
An antigenic and/or immunogenic fragment of a protein or polypeptide as defined in Tables 1-3.
A nucleic acid molecule comprising or consisting of a sequence which is:
- (i) any of the DNA sequences set out in Table 1 or their RNA equivalents;
- (ii) a sequence which is complementary to any of the sequences of (i);
- (iii) a sequence which codes for the same protein or polypeptide, as those sequences of (i) or (ii);
- (iv) a sequence which is substantially identical with any of those of (i), (ii) and (iii);
- (v) a sequence which codes for a homologue, derivative or fragment of a protein as defined in Table 1.
A nucleic acid molecule comprising or consisting of a sequence which is:
- (i) any of the DNA sequences set out in Table 2 or their RNA equivalents;
- (ii) a sequence which is complementary to any of the sequences of (i);
- (iii) a sequence which codes for the same protein or polypeptide, as those sequences of (i) or (ii);
- (iv) a sequence which is substantially identical with any of those of (i), (ii) and (iii);
- (v) a sequence which codes for a homologue, derivative or fragment of a protein as defined in Table 2.
The use of a protein or polypeptide having a sequence selected from those shown in Tables 1-3, or homologues, derivatives and/or fragments thereof, as an immunogen and/or antigen.
An immunogenic and/or antigenic composition comprising one or more proteins or polypeptides selected from those whose sequences are shown in Tables 1-3, or homologues or derivatives thereof, and/or fragments of any of these.
A vaccine composition comprising one or more nucleic acid sequences as defined in Tables 1-3.
A method for the detection/diagnosis of S.pneumoniae which comprises the step of bringing into contact a sample to be tested with at least one protein or polypeptide as defined in Tables 1-3, or homologue, derivative or fragment thereof.
An antibody capable of binding to a protein or polypeptide as defined in Tables 1-3, or for a homologue, derivative or fragment thereof.
A method of determining whether a protein or polypeptide as defined in Tables 1-3 represents a potential anti-microbial target which comprises inactivating said protein or polypeptide and determining whether S.pneumoniae is still viable.
The use of an agent capable of antagonising, inhibiting or otherwise interfering with the function or expression of a protein or polypeptide as defined in Tables 1-3 in the manufacture of a medicament for use in the treatment or prophylaxis of S.pneumoniae infection.
Dependencies are inferred from the claim text.