Recovery of tissue function following administration of B cells to injured tissue
AssigneeActX, Inc.
InventorsMark Poznansky, Traci Goodchild, Mark Ungs, Nicholas Chronos, Nadine Weich
Life of this patent
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Abstract
The present invention relates generally to systems and methods of enhancing recovery of function of injured tissue through administration of a composition comprising a relatively pure populations of B lymphocyte cells in a pharmaceutically acceptable carrier to the injured tissue. Kits are provided to aid in purification of B cells from heterogeneous mixtures of cells and administration of B cells to injured tissue.
Claims20
A method of treating injured tissue in an animal or a human comprising administering an amount of a composition comprising a relatively pure population of B cells in a pharmaceutically acceptable carrier to the animal or the human with the injured tissue, wherein the amount is effective to treat the injured tissue.
A method of treating injured tissue in an animal or a human comprising administering a substance to the animal or the human that increases B cell concentration at the injured tissue in the animal or the human.
A system for treating injured tissue in an animal or a human comprising:
- obtaining a sample containing B cells from the animal or the human with the injured tissue;
- purifying the sample to produce a relatively pure population of B cells;
- combining the relatively pure population of B cells with a pharmaceutically acceptable carrier to produce a composition;
- and,
- administering the composition to the animal or the human with the injured tissue in an amount effective to treat the injured tissue in the animal or the human.
A kit useful for isolating human B cells from a heterogeneous population of human cells comprising:
- a separation chamber containing a centrifugation chamber;
- connection units;
- connection lines;
- a collection bag;
- antibodies capable of recognizing antigens on the human B cells, wherein the antibodies are linked to magnetic particles;
- a filter;
- a collection tube;
- and,
- instructions for using the kit.
A kit useful for isolating human B cells from a heterogeneous population of human cells comprising:
- a separation chamber containing a centrifugation chamber;
- connection units;
- connection lines;
- a collection bag;
- antibodies capable of recognizing antigens on the cells in the heterogeneous population of human cells that are not B cells, wherein the antibodies are linked to a medium;
- a collection tube;
- and,
- instructions for using the kit.
Dependencies are inferred from the claim text.