US 2006/0263273 A1 · Reaction block for parallel synthetic chemistry and vessel therefor

Abstract

A reaction vessel for use in an apparatus for parallel synthetic chemistry with a reaction chamber space for containing contents of a chemical reaction and a discharge channel for selectively removing liquid contents of the reaction chamber. The invention includes an apparatus for receiving a plurality of the reaction vessels, a method for using the apparatus and a method for forming the vessels.

Claims42

Dependent claims

A reaction vessel for performing chemical reactions, which comprises:

(a) a single-piece body made of a polymeric material, the body defining a reaction chamber, a connection channel, and a discharge channel, each having an interior space;
(b) the reaction chamber and the discharge channel each having an upper end with an opening therein;
(c) the reaction chamber and the discharge channel each having a bottom portion with an orifice therein;
(d) the reaction chamber and the discharge channel each tapering from the open upper end toward the bottom portion with decreasing cross-sectional area;
and
(e) the connection channel extending from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel with constant or decreasing cross-section thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber.

3 more elements

A reactor block for performing a multiplicity of chemical reactions simultaneously, comprising:

I. a vessel holder having at least two rows of at least two locations configured and dimensioned to receive a reaction vessel, wherein the reaction vessel comprises:
(a) a single-piece body made of a polymeric material, the body defining a reaction chamber having an interior space, a connection channel, and a discharge channel;
(b) the reaction chamber and the discharge channel each having an upper end with an opening therein;
(c) the reaction chamber and the discharge channel each having a bottom portion with an orifice therein;
(d) the reaction chamber and the discharge channel each tapering from the open upper end toward the bottom portion with decreasing cross-section;
and
(e) the connection channel tapering from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel with constant or decreasing cross-section thereby fluidically connecting the discharge channel with the interior space of the reaction chamber;
and
II. first closure means having openings, wherein,
(a) the first closure means is movable in a sliding manner over the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels when the reaction vessels are received in the locations, and
(b) the first closure means is slidable from a first position to a second position so that in the first position when the reaction vessels are received in the locations, the openings in the first closure means allow access to the openings of the upper ends of the reaction chamber and discharge channel of each vessel, and in the second position, the openings of the upper ends of the reaction chamber and discharge channel are closed by the first closure means resting on the open upper ends of the reaction chamber and discharge channel.

8 more elements

A reactor block for performing a multiplicity of chemical reactions simultaneously comprising:

I. a vessel holder having at least two rows of at least two locations configured and dimensioned to receive a reaction vessel, wherein the reaction vessel comprises:
(a) a single-piece body made of a polymeric material, shaped by injection molding using a mold and at least one core with a movable attached extension, the body defining a reaction chamber having an interior space, a connection channel and a discharge channel;
(b) the reaction chamber and the discharge channel each having an upper end with an opening therein;
(c) the reaction chamber and the discharge channel each having a bottom portion, with each bottom portion having an orifice therein;
(d) the reaction chamber and the discharge channel each tapering from the open upper end towards the bottom portion with decreasing cross-section;
(e) the connection channel being formed by the movable, attached extension of the core which is extracted from the connection channel through the reaction chamber or through the discharge channel after injection molding;
and
(f) the connection channel extending between the orifice of the bottom portion of the reaction chamber orifice and the orifice of the bottom portion of the discharge channel thereby fluidically connecting the discharge channel with the interior space of the reaction chamber;
and
II. first closure means having openings, wherein,
(a) the first closure means is movable in a sliding manner over the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels when the reaction vessels are received in the locations, and
(b) the first closure means is slidable from a first position to a second position so that in the first position when the reaction vessels are received in the locations, the openings in the first closure means allow access to the openings of the upper ends of the reaction chamber and discharge channel of each vessel, and in the second position, the openings of the upper ends of the reaction chamber and discharge channel are closed by the first closure means resting on the open upper ends of the reaction chamber and discharge channel.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

11/491,447Filed 21 Jul 2006

Priority

EP 01810859.77 Sep 2001

Published

23 Nov 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

B01L 3/5025
With fluid transport, e.g. in multi-compartment structures: for parallel transport of multiple samples
B01J 19/0046
Chemical, physical or physico-chemical processes in general; Their relevant apparatus: sequential or parallel reactions, e.g. for the synthesis of…
B29C 45/4471
For undercut articles: using flexible or pivotable undercut forming elements
B01J 2219/00283
Individual reactor vessels: reactor vessels with top opening

Abstract

Claims42

Dependent claims

A reaction vessel for performing chemical reactions, which comprises:

(a) a single-piece body made of a polymeric material, the body defining a reaction chamber, a connection channel, and a discharge channel, each having an interior space;
(b) the reaction chamber and the discharge channel each having an upper end with an opening therein;
(c) the reaction chamber and the discharge channel each having a bottom portion with an orifice therein;
(d) the reaction chamber and the discharge channel each tapering from the open upper end toward the bottom portion with decreasing cross-sectional area;
and
(e) the connection channel extending from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel with constant or decreasing cross-section thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber.

3 more elements

A reactor block for performing a multiplicity of chemical reactions simultaneously, comprising:

I. a vessel holder having at least two rows of at least two locations configured and dimensioned to receive a reaction vessel, wherein the reaction vessel comprises:
(a) a single-piece body made of a polymeric material, the body defining a reaction chamber having an interior space, a connection channel, and a discharge channel;
(b) the reaction chamber and the discharge channel each having an upper end with an opening therein;
(c) the reaction chamber and the discharge channel each having a bottom portion with an orifice therein;
(d) the reaction chamber and the discharge channel each tapering from the open upper end toward the bottom portion with decreasing cross-section;
and
(e) the connection channel tapering from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel with constant or decreasing cross-section thereby fluidically connecting the discharge channel with the interior space of the reaction chamber;
and
II. first closure means having openings, wherein,
(a) the first closure means is movable in a sliding manner over the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels when the reaction vessels are received in the locations, and
(b) the first closure means is slidable from a first position to a second position so that in the first position when the reaction vessels are received in the locations, the openings in the first closure means allow access to the openings of the upper ends of the reaction chamber and discharge channel of each vessel, and in the second position, the openings of the upper ends of the reaction chamber and discharge channel are closed by the first closure means resting on the open upper ends of the reaction chamber and discharge channel.

8 more elements

A reactor block for performing a multiplicity of chemical reactions simultaneously comprising:

I. a vessel holder having at least two rows of at least two locations configured and dimensioned to receive a reaction vessel, wherein the reaction vessel comprises:
(a) a single-piece body made of a polymeric material, shaped by injection molding using a mold and at least one core with a movable attached extension, the body defining a reaction chamber having an interior space, a connection channel and a discharge channel;
(b) the reaction chamber and the discharge channel each having an upper end with an opening therein;
(c) the reaction chamber and the discharge channel each having a bottom portion, with each bottom portion having an orifice therein;
(d) the reaction chamber and the discharge channel each tapering from the open upper end towards the bottom portion with decreasing cross-section;
(e) the connection channel being formed by the movable, attached extension of the core which is extracted from the connection channel through the reaction chamber or through the discharge channel after injection molding;
and
(f) the connection channel extending between the orifice of the bottom portion of the reaction chamber orifice and the orifice of the bottom portion of the discharge channel thereby fluidically connecting the discharge channel with the interior space of the reaction chamber;
and
II. first closure means having openings, wherein,
(a) the first closure means is movable in a sliding manner over the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels when the reaction vessels are received in the locations, and
(b) the first closure means is slidable from a first position to a second position so that in the first position when the reaction vessels are received in the locations, the openings in the first closure means allow access to the openings of the upper ends of the reaction chamber and discharge channel of each vessel, and in the second position, the openings of the upper ends of the reaction chamber and discharge channel are closed by the first closure means resting on the open upper ends of the reaction chamber and discharge channel.

9 more elements

Dependencies are inferred from the claim text.

Reaction block for parallel synthetic chemistry and vessel therefor

Life of this patent

Abstract

Claims42

Reaction block for parallel synthetic chemistry and vessel therefor

Life of this patent

Abstract

Claims42