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US 2006/0251681 A1Published application
Methods for producing Marburg Virus proteins
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsMichael Heyey, Diane Negley, Peter Pushko, Jonathan Smith, Alan Schmaljohn
Life of this patent
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Abstract
Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
Claims4
1-19. (canceled)
A method for producing Marburg virus proteins comprising culturing a prokaryotic host cell transformed with a recombinant DNA construct comprising
- (i) a Venezuelan equine encephalitis replicon vector, and
- (ii) at least one DNA fragment encoding any one of the Marburg virus proteins GP, NP, VP40, VP35, VP30, VP24 and GPΔTM,
- under conditions such that said DNA fragment is expressed and said Marburg virus protein is produced.
A method for producing Marburg virus proteins comprising culturing a eukaryotic host cell transformed with a recombinant DNA construct comprising
- (i) a Venezuelan equine encephalitis replicon vector, and
- (iii) at least one DNA fragment encoding any one of the Marburg virus proteins GP, NP, VP40, VP35, VP30, VP24 and GPΔTM,
- under conditions such that said DNA fragment is expressed and said Marburg virus protein is produced.
22-24. (canceled)
Dependencies are inferred from the claim text.