Disease model animal carrying foreign ppar alpha gene transferred thereinto and use thereof
OwnerYuichiro Amano, Yasuo Sugiyama +2inventors
InventorsYuichiro Amano, Yasuo Sugiyama, Mayumi Nishida, Shigehisa Taketomi
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Abstract
The present invention provides a non-human mammal, or a part of its living body, which stably retains a DNA encoding a heterologous PPARα in an expressible state, and has one or more different genetic modifications resulting in a pathological condition identical or similar to a disease associated with the regulation of PPARα activity or a foreign DNA under the control of a promoter having PPRE, as well as a method of screening for agonists/antagonists for the heterologous PPARα using the animal.
Claims16
A non-human mammal, which stably retains a DNA encoding a heterologous PPARα in an expressible state and has one or more different genetic modifications, or a part of its living body.
Dependencies are inferred from the claim text.