Vertebral disc repair
AssigneeMusculoskeletal Transplant Foundation
InventorsArthur Gertzman, Barbara Merboth, Michael Schuler, Anton Steiner, Eric Semlar, Judith Yannariello-Brown
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Abstract
A sterile implant for treatment of a spinal disc defect comprising an allograft cortical bone demineralized to a Type I collagen having a specific shape which is treated to eliminate osteoinductivity. The implant is lyophilized and compressed into smaller first shape which 20 to 80% from its original shape in at least one dimension and hardened. The implant expanding when hydrated into a second shape having the shape memory of the first shape and expanded in dimensional size from the first compressed shape.
Claims28
A sterile implant for non-fusion spinal disc repair comprising substantially demineralized bone implant treated to be non-osteoinductive, said implant possessing a specific original shape, is compressed into a smaller second shape, from which said implant is capable of exhibiting shape-memory upon re-hydration with a fluid.
A sterile implant for non-fusion spinal disc repair comprising substantially demineralized human cortical bone of less than 0.2% wt/wt residual calcium formed of Type I collagen treated to be non-osteoinductive, said implant having a pH ranging from 6.6 to 7.4 and possessing a specific original shape which is compressed by 20-50% in at least one dimension and hardened into a smaller second shape, from which said second shape said implant is capable of expansion and exhibiting shape-memory when contacted with a fluid.
A process for producing a sterile implant for insertion into the nucleus pulposus of a spinal disc comprising the steps of:
- a. forming a bone portion into a desired initial configuration;
- b. demineralizing said bone portion;
- c. treating the demineralized bone portion to preclude osteoinductivity;
- d. treating the demineralized bone portion to obtain a pH ranging from about 6.6 to about 7.4;
- e. reshaping the formed configuration from its original configuration by compaction into a smaller second shape;
- f. hardening the configuration by lyophilization;
- and
- g. packaging the formed configuration into a sterile package.
Dependencies are inferred from the claim text.