Methods and apparatus for multi-vessel renal neuromodulation
AssigneeArdian, Inc.
InventorDenise Demarais
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Abstract
Methods and apparatus are provided for multi-vessel neuromodulation, e.g., via a pulsed electric field. Such multi-vessel neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, the multi-vessel neuromodulation is applied to neural fibers that contribute to renal function. Such multi-vessel neuromodulation optionally may be performed bilaterally.
Claims32
A method for multi-vessel renal neuromodulation of a patient, the method comprising:
- placing a first electrode in a first vessel of a patient in proximity to a neural fiber that contributes to a function of a kidney of the patient;
- placing a second electrode in a second vessel of the patient, wherein the second vessel is a different vessel than the first vessel;
- and
- passing electrical current through the first electrode and the second electrode to modulate the function of the neural fiber.
A method for a renal neuromodulation of a patient, the method comprising:
- placing a first electrode within a first vessel of a patient at least substantially proximate to a neural fiber that contributes to a function of a kidney of the patient;
- placing a second electrode within a second vessel of the patient, wherein the second vessel is a different vessel than the first vessel;
- and
- delivering an electric field between the first electrode and the second electrode such that the resulting electric field is generally aligned with a longitudinal axis of a renal artery associated with the kidney, thereby modulating the function of the neural fiber.
Apparatus for performing renal neuromodulation of a patient, the apparatus comprising:
- a pulsed electric field generator;
- a first element configured for placement within a first vessel of the patient, the first element comprising a first electrode electrically coupled to the pulsed electric field generator;
- and
- a second element configured for placement within a second vessel of the patient that is different than the first vessel, the second element comprising a second electrode electrically coupled to the pulsed electric field generator,
- wherein the apparatus is configured for delivery of a pulsed electric field between the first electrode and the second electrode to modulate a neural fiber that contributes to renal function while the first device is located within the first vessel and the second device is located within the second vessel.
Dependencies are inferred from the claim text.