US 2006/0235239 A1 · Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same

Abstract

The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative disease in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl derivative of the present invention can effectively be used to prevent and treat chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, degenerative brain disease such as epilepsy and ischemic brain disease such as stroke.

Claims15

Dependent claims

A tetrafluorobenzyl derivative represented by the following chemical formula:

wherein,
R1, R2 and R3 are hydrogen or halogen,
R4 is hydroxy, alkoxy or alkoxy substituted with halogen, and
R5 is carboxyl acid or ester having C1-C4;
or
a pharmaceutically acceptable salt thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

11/450,596Filed 8 Jun 2006

Priority

KR 10-2002-3425919 Jun 2002

Published

19 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification26 codes

C07C 215/76
Having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton: of the same non-condensed…
A61K 31/136
Having aromatic rings , e.g. ketamine, nortriptyline: having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61P 9/00
Drugs for disorders of the cardiovascular system
A61P 9/10
Drugs for disorders of the cardiovascular system: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary…

Family

Application10/481,648Division · filed 22 Dec 2003

Application11/165,293Division · filed 22 Jun 2005

Application11/450,596Division · filed 8 Jun 2006

US 2004/0209957 A1Published application

US 2005/0239896 A1Published application

US 6,927,303 B2Related patent

US 7,189,878 B2Related patent

US 7,371,896 B2Related patent

US 2006/0235239 A1This patent

From the US filing history. Foreign family members aren’t listed.

Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same

Life of this patent

Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same

Life of this patent

Abstract

Claims15