Histone deacetylase inhibitors

A compound of general formula (I):

• in which:
• R1 may be (C6 or C10) aryl, (C6 or C10) arylalkyl, (C6 or C10) heteroaryl, (C3-C8) heterocycloalkenyl, (C5-C8) cycloalkene ring, (C5-C8) cycloalkyl, (C5-C8) heterocycloalkyl or a combination thereof to form a linked or fused ring system, the cyclic moiety being optionally substituted with (C1-C10) alkyl, (C1-C10) alkenyl, (C1-C10) alkynyl, (C1-C10) alkoxy, (C1-C10) thioalkoxy, hydroxyl, hydroxyl, (C1-C10) hydroxylalkyl, halo, (C1-C10) haloalkyl, amino, amido, (C1-C10) alkylamino, (C1-C10) alkylcarbonyloxy, (C1-C10) alkoxycarbonyl, (C1-C10) alkylcarbonyl, (C1-C10) alkylthiocarbonyl, (C1-C10) alkylsulfonylamino, aminosulfonyl, (C1-C10) alkylsulfinyl, or (C1-C10) alkylsulfonyl,
• R2 and R3 may each independently be hydrogen, (C1-C12) alkyl, substituted (C1-C12) alkyl, or unsaturated (C1-C12) comprising one or more C═C bond or C≡C bond, (C6 or C10) aryl or (C6 or C10) heteroaryl, or a combination thereof to form a linked or fused ring system, or (C1-C10) alkyl, (C1-C10) alkenyl, (C1-C10) alkynyl, (C1-C10) alkoxy, (C1-C10) thioalkoxy, hydroxyl, hydroxyl, (C1-C10) hydroxylalkyl, halo, (C1-C10) haloalkyl, cyano, nitro, amino, amido, (C1-C10) alkylamino, (C1-C10) alkylcarbonyloxy, (C1-C10) alkoxycarbonyl, (C1-C10) alkylcarbonyl, (C1-C10) alkylthiocarbonyl, (C1-C10) alkylsulfonylamino, aminosulfonyl, (C1-C10) alkylsulfinyl, or (C1-C10) alkylsulfonyl, in which the saturated or an unsaturated hydrocarbon chain is optionally interrupted by O, S, NR, CO, C(NR), N(R)SO2, SO2N(R), N(R)C(O)O, OC(O)N(R), N(R)C(O)N(R), OC(O), C(O)O, OSO2, SO2O, or OC(O)O, where R may be independently hydrogen, (C1-C10) alkyl, (C1-C10) alkenyl, (C1-C10) alkynyl, (C1-C10) alkoxy, (C1-C10) hydroxylalkyl, hydroxyl, (C1-C10) halolalkyl, where each of the saturated or unsaturated hydrocarbon chains may be optionally substituted with (C1-C10) alkyl, (C1-C10) alkenyl, (C1-C10) alkynyl, (C1-C10) alkoxy, hydroxyl, hydroxyl, (C1-C10) hydroxylalkyl, halo, (C1-C10) haloalkyl, amino, (C1-C10) alkylcarbonyloxy, (C1-C10) alkoxycarbonyl, (C1-C10) alkylcarbonyl, (C1-C10) alkylsulfonylamino, aminosulfonyl, or (C1-C10) alkylsulfonyl,
• or R2 and R3 optionally form a (C6 or C10) aryl, (C6 or C10) arylalkyl, (C6 or C10) heteroaryl, (C3-C8) heterocycloalkenyl, (C5-C8) cycloalkene ring, (C5-C8) cycloalkyl, (C5-C8) heterocycloalkyl linked or fused ring system, optionally containing up to 3 heteroatoms, e.g. oxygen, nitrogen, sulphur or phosphorous.
• or R1 and R2 optionally form a (C6 or C10) aryl, (C6 or C10) arylalkyl, (C6 or C10) heteroaryl, (C3-C8) heterocycloalkenyl, (C5-C8) cycloalkene ring, (C5-C8) cycloalkyl, (C5-C8) heterocycloalkyl linked or fused ring system, optionally the ring formed may be further substituted with a group R1 as defined above, or the ring formed may be fused to a further C6 aryl group which may be optionally substituted with a group R1 as defined above, or a group R1R2N, with R1 and R2 as defined above,
• n may be equal to 0, 1 or 2,
• X may be hydroxyl (—OH), —OR, NHR, hydroxamate (—NHOH), NHOR, NROR, NRNHR, or SR
• where each group R may independently be hydrogen, C1-C6 alkyl or substituted C1-C6 alkyl,
• Y may be 0, 1 or 2 oxygen atoms, or NR where R may be H, OH, OR or a carbon atom, where R may be C1-C6 alkyl or substituted C1-C6 alkyl;
• and
• Q represents
• wherein m is an integer from 1 to 4;
• n is an integer from 1 to 8;
• and R4 and R5 each independently represents hydrogen, unsubstituted or substituted C1-C10 alkyl, an unsaturated hydrocarbon chain of up to ten carbon atoms comprising one or more carbon-carbon double bonds, C6 or C10 aryl, a 5- to 10-membered heterocyclic group, C1-C10 alkoxy, C1-C10 thioalkoxy, hydroxyl, halo, cyano, nitro, amino, amido, (C1-C10 alkyl)carbonyloxy, (C1-C10 alkoxy)carbonyl, (C1-C10 alkyl)carbonyl, (C1-C10 alkyl)thiocarbonyl, (C1-C10 alkyl)suflonylamino, aminosulfonyl, C1-C10 alkylsulfinyl, C1-C10 alkylsulfonyl, or a saturated or unsaturated C3-C12 hydrocarbon chain interrupted by O, S, NR, CO, C(NR), N(R)SO2, SO2N(R), N(R)C(O)O, OC(O)N(R), N(R)C(O)N(R), OC(O), C(O)O, OSO2, SO2O or OC(O)O where R is as defined above and the saturated or unsaturated hydrocarbon chain is optionally substituted as defined above;
• or a pharmaceutically acceptable salt thereof.