Indole-derivative modulators of steroid hormone nuclear receptors

A compound of the formula:

• wherein,
• R1 represents (C3-C7)cycloalkyl, (C2-C6)alkynyl, aryl, heterocycle, fused heterocycle, or a substituted aryl, heterocycle, or fused heterocycle;
• R2 represents (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, substituted aryl, heterocycle, substituted heterocycle, (C1-C4)alkyl-(C3-C7)cycloalkyl, (C1-C4)alkyl-heterocycle, (C1-C4)alkyl-substituted heterocycle, (C1-C4)alkyl-aryl, (C1-C4)alkyl-substituted aryl, halo(C1-C6)alkyl, (C1-C4)alkyl-(C1-C6)alkoxy, (C2-C6)alkenyl, (C2-C6)alkynyl, cyano(C1-C6)alkyl, nitro(C1-C6)alkyl, amino(C1-C6)alkyl, NH(C1-C4)alkylamine, N,N—(C1-C4)dialkylamine(C1-C4)alkyl-NH(C1-C4)alkylamine, or (C1-C4)alkyl-N,N—(C1-C4)dialkylamine;
• R3 represents (C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C4)alkyl-(C3-C7)cycloalkyl, (C1-C6)alkoxy, (C1-C4)alkyl-(C1-C6)alkoxy, aryl or R2 and R3 together with the carbon atom to which they are attached form a (C3-C7)cycloalkyl or heterocycle group, with the proviso that where R1 through R3 all represent aryl, then at least one of R4, R5 or R7 is other than hydrogen;
• R4 represents halo, amino, nitro, (C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, NHSO2R8, N(CH3)SO2R8, NHCOR12, SO2R9 or CHO;
• R5 represents hydrogen, halo, hydroxyl, amino, nitro, cyano, difluoromethyl, triflouromethyl, difluoromethoxy, triflouromethoxy, (C1-C6)alkyl, or OR11;
• R6 represents hydrogen, halo, (C1-C6)alkyl, or (C3-C7)cycloalkyl;
• R7 represents hydrogen, (C1-C6)alkyl, or (C1-C4)alkyl-COOH;
• R8 and R9 each independently represent at each occurrence amino, (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, substituted aryl, (C1-C4)alkyl-aryl, (C1-C4)alkyl-substituted aryl, heterocycle, substituted heterocycle, (C1-C4)alkyl-heterocycle, (C1-C4)alkyl-substituted heterocycle, NH(C1-C4)alkylamine, or N,N—(C1-C4)dialkylamine;
• R10 and R11 each independently represent (C3-C7)cycloalkyl, aryl, substituted aryl, (C1-C4)alkyl-aryl, (C1-C4)alkyl-substituted aryl, heterocycle, substituted heterocycle, (C1-C4)alkyl-heterocycle, or (C1-C4)alkyl-substituted heterocycle;
• and
• R12 represents (C1-C6)alkyl,
• provided that where R1 through R3 all represent aryl, then at least one of R4, R5 or R7 is other than hydrogen;
• or a pharmaceutically acceptable salt thereof.