Use of anti-tissue factor antibodies for treating thromboses
OwnerJin-An Jiao, Hing Wong +2inventors
InventorsJin-An Jiao, Hing Wong, Esperanza Nieves, Luis Mosquera
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Abstract
Disclosed is a method for preventing or treating thrombosis in a mammal such as a primate and particularly a human patient. A preferred method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to human tissue factor (TF). Additional methods and kits are provided.
Claims32
A method for preventing or treating a thrombosis in a mammal, the method comprising administering to the mammal a therapeutically effective amount of at least one antibody, or fragment thereof that binds specifically to human tissue factor (TF) to form a complex, the administration being sufficient to prevent or treat the thrombosis in the mammal, wherein the antibody or the fragment has a binding specificity for the TF about equal or greater than the antibody obtained from cell line H36.D2.B7 deposited under ATCC Accession No. HB-12255
A method for performing plastic, reconstructive, or transplant surgery in a mammal, the method comprising introducing a graft into the mammal and contacting the graft with a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to human tissue factor (TF) to form a complex, the contact being sufficient to maintain or increase patency of the graft, wherein the humanized antibody, chimeric antibody or the fragment has a binding specificity for the TF about equal or greater than the antibody obtained from cell line H36.D2.B7 deposited under ATCC Accession No. HB-12255
Dependencies are inferred from the claim text.