BMP-2 variants with improved properties

A non-naturally occuring variant BMP-2 protein comprising at least one substitution as compared to an amino acid sequence comprising SEQ ID NO:1, said substitution selected from the group consisting of:

• S12E, S13K, K15D, P18R, P18T, S24N, S24Q, N29D, N29S, W31A, W31E, W31N, W31Q, P36K, P36Q, P36R, P36S, P36T, H39E, H39Q, F41D, F41N, E46Q, D53Q, D53T, Q64E, L66E, L66N, L66Q, S69A, S69D, S69R, S69F, V70E, V70K, V70Q, V70T, N71K, S72D, S85E, A86D, L90E, L90K, Y91D, Y91E, Y91K, Y91T, N95D, N95S, E96D, E96S, E96N, V98A, V98D, V98R, V98T, L100A, L100E, L100K, L100Q, Y103D, Q104D, and E109R.