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US 2006/0235201 A1Published application
Enduring T cell response
OwnerRoman Kischelinventor
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OwnerRoman Kischelinventor
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The present invention provides a trimeric polypeptide construct, wherein each monomer of the trimeric polypeptide construct consists of two or three domains, and wherein the first domain is the extracellular domain of 4-1BBL or (a) part(s) thereof, the second domain consists of an antigen-interaction-site which is located N-terminally of the first domain and, optionally, the third domain combines said first and second domain via a peptide linker, wherein said peptide linker does not comprise any polymerization activity. Further, the invention provides nucleic acid molecules encoding said polypeptide constructs, vectors and hast systems for the expression of the trimeric polypeptide construct. Moreover, the invention provides compositions which are envisaged to be pharmaceutical compositions and their use in the treatment of diseases.
A trimeric polypeptide construct, wherein each monomer of the trimeric polypeptide construct consists of two or three domains, and wherein the first domain is the extracellular domain of 4-1BBL or (a) part(s) thereof, the second domain comprises an antigen-interaction-site which is located N terminally of the first domain and, optionally, the third domain combines said first and second domain via a peptide linker, wherein said peptide linker does not comprise any polymerization activity.
The trimeric polypeptide construct of any of 12, wherein said second domain of each monomer comprises a scFv specific for EpCAM and an antigen interaction site which is the extracellular domain of B7.1 or a fragment or a derivative thereof which is capable of binding to its specific receptor.
Dependencies are inferred from the claim text.