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OwnerHisakazu Mihara, Tsuyoshi Takahashi +1inventors
InventorsHisakazu Mihara, Tsuyoshi Takahashi, Hideo Ooshima
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There are disclosed a natural peptide search in which a template reaction with the nucleus of a minute amount of amyloid β-protein having undergone amyloid fibrosis is induced so as to form amyloid fibers, followed by fiber amount increase and amplification; designing and development of a novel artificial peptide which can be a substitute therefor; a method of amplifying the amyloid fibrosis of amyloid β-protein with the use thereof and a reagent for use therein; and a method of detecting disease caused by amyloidosis and a reagent for use therein. In particular, there are provided a method of amplifying the amyloid fibrosis of amyloid β-protein with the use of a reagent comprising a peptide composed of 14 to 23 residues of amyloid β-peptide or a peptide resulting from substitution of all the positive-charge side chain amino acids of the peptide with Lys and substitution of all the negative-charge side chain amino acids thereof with Glu; a reagent for use therein; a method of detecting disease caused by amyloidosis with the use of a reagent comprising the above peptide; a reagent for use therein; and a novel artificial peptide which can be used therein.
A reagent for amplifying the amyloid fibrosis of amyloid β-protein, which comprises a peptide consisting of 14 to 23 residues of amyloid β-peptide [hereinafter, abbreviated as Aβ (14-23)] or a peptide derived from the peptide by substituting all positively charged side-chain amino acids thereof with Lys and simultaneously substituting all negatively charged side-chain amino acids thereof with Glu.
A method of amplifying the amyloid fibrosis of amyloid β-protein, which comprises using a reagent containing a peptide [Aβ (14-23)] consisting of 14 to 23 residues of amyloid β-peptide or a peptide derived from the peptide by substituting all positively charged side-chain amino acids thereof with Lys and simultaneously substituting all negatively charged side-chain amino acids thereof with Glu.
A reagent for detection of disease attributable to amyloidosis, which comprises a peptide [Aβ (14-23)] consisting of 14 to 23 residues of amyloid β-peptide or a peptide derived from the peptide by substituting all positively charged side-chain amino acids thereof with Lys and simultaneously substituting all negatively charged side-chain amino acids thereof with Glu.
A method of detecting disease attributable to amyloidosis, which comprises using a reagent containing a peptide [Aβ (14-23)] consisting of 14 to 23 residues of amyloid β-peptide or a peptide derived from the peptide by substituting all positively charged side-chain amino acids thereof with Lys and simultaneously substituting all negatively charged side-chain amino acids thereof with Glu.
A peptide represented by the following general formula [1]:
Dependencies are inferred from the claim text.