Metal colloid solution
AssigneeAsahi Kasei Medical Co., Ltd.
InventorsTomoko Hongo, Naoko Hamasaki, Shoichi Ide, Fumihiko Yamaguchi, Mitsunori Kubozaki
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Abstract
A colloid solution that exhibits storage stability and pH stability, being useful as viral substitute particles for use in an integrity test for virus removal membrane. In particular, a metal colloid solution characterized in that it comprises metal particles or metal compound particles of 1 to 100 nm average diameter, a water soluble high-molecular-weight dispersant having an N group and water and/or a water soluble organic solvent, the metal colloid solution being stable for a prolonged period of time and being stable in at least pH values ranging from 4 to 11.
Claims31
1-33. (canceled)
A colloid solution of metal particles or metal compound particles comprising at least
- (1) metal particles or metal compound particles having an average particle diameter of 1-100 nm,
- (2) a water-soluble high molecular weight dispersant containing an N group, and
- (3) water and/or a water-soluble organic solvent, and having the following properties (a) and (b):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11, and
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5.
A colloid solution of metal particles or metal compound particles comprising
- (1) metal particles or metal compound particles having an average particle diameter of 15-40 nm, and the percent of variation in the particle diameter distribution of 30% or less,
- (2) a water-soluble high molecular weight dispersant containing an N group,
- (3) water and/or a water-soluble organic solvent, further
- (4) a surfactant and/or a chelating agent and having the following properties (a), (b) and (c):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11,
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5, and
- (c) in the colloid solution achieving a colloid recovery rate of 70% or more when the colloid solution is filtered through a collection test porous membrane and satisfying the following conditions:
- (average pore diameter (nm) of the collection test porous membrane)−(average particle diameter (nm) of colloid)>10 nm.
A method for producing a colloid solution of metal particles or metal compound particles, in which the colloid solution comprise at least
- (1) metal particles or metal compound particles having an average particle diameter of 1-100 nm,
- (2) a water-soluble high molecular weight dispersant containing an N group, and
- (3) water and/or a water-soluble organic solvent, and has the following properties (a) and (b):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11 and
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5, characterized in that the method comprises adding a surfactant and/or a chelating agent after adding a water-soluble high molecular weight dispersant containing an N group to the colloid solution of metal particles or metal compound particles.
A method for producing a colloid solution of metal particles or metal compound particles, in which the colloid solution comprise at least
- (1) metal particles or metal compound particles having an average particle diameter of 15-40 nm, and the percent of variation in the particle diameter distribution of 30% or less,
- (2) a water-soluble high molecular weight dispersant containing an N group,
- (3) water and/or a water-soluble organic solvent, further
- (4) a surfactant and/or a chelating agent and has the following properties (a), (b) and (c):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11,
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5, and
- (c) having a colloid recovery rate of 70% or more when the colloid solution is filtered through a collection test porous membrane and satisfying the following conditions:
- (average pore diameter (nm) of the collection test porous membrane)−(average particle diameter (nm) of colloid)>10 nm,
- characterized in that the method comprises adding the surfactant and/or chelating agent after adding the water-soluble high molecular weight dispersant containing an N group to the colloid solution of metal particles or metal compound particles.
An adsorption preventive agent capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being adsorbed on a porous membrane, in which the colloid solution comprises (1) a water-soluble high molecular weight dispersant containing an N group and/or (2) a surfactant and/or a chelating agent as effective components.
An adsorption preventive agent capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being adsorbed on a porous membrane, characterized in that the colloid solution contains at least
- (1) metal particles or metal compound particles having an average particle diameter of 1-100 nm,
- (2) a water-soluble high molecular weight dispersant containing an N group, and
- (3) water and/or a water-soluble organic solvent, and has the following properties (a) and (b):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11 and
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5.
An adsorption preventive agent capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being adsorbed on a porous membrane, characterized in that the colloid solution comprises at least
- (1) metal particles or metal compound particles having an average particle diameter of 15 to 40 nm, and the percent of variation in the particle diameter distribution of 30% or less,
- (2) a water-soluble high molecular weight dispersant containing an N group, and
- (3) water and/or a water-soluble organic solvent, further
- (4) a surfactant and/or a chelating agent and has the following properties (a), (b) and (c):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11 and
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5,
- (c) achieving a colloid recovery rate of 70% or more when the colloid solution is filtered through a collection test porous membrane and satisfying the following conditions:
- (average pore diameter (nm) of the collection test porous membrane)−(average particle diameter (nm) of colloid)>10 nm.
An adsorption preventive agent capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being absorbed on a cellulose-type porous membrane, in which the colloid solution contains (1) a water-soluble high molecular weight dispersant containing an N group, and (2) a surfactant, or a surfactant and a chelating agent as effective components.
An adsorption preventive agent capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being absorbed on a porous membrane of synthetic polymer, in which the colloid solution contains (1) a water-soluble high molecular weight dispersant containing an N group, and (2) a chelating agent as effective components, provided that the colloid solution does not contain a surfactant.
An adsorption preventive method capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being absorbed on a porous membrane, in which the colloid solution contains (1) a water-soluble high molecular weight dispersant containing an N group and/or (2) a surfactant and/or a chelating agent as effective components.
An adsorption preventive method capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being absorbed on a porous membrane, characterized in that the colloid solution contains at least
- (1) metal particles or metal compound particles having an average particle diameter of 1-100 nm,
- (2) a water-soluble high molecular weight dispersant containing an N group and
- (3) water and/or a water-soluble organic solvent, and the colloid solution has the following properties (a) and (b):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11 and
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5.
An adsorption preventive method capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being absorbed on a cellulose-type porous membrane, in which the colloid solution contains (1) a water-soluble high molecular weight dispersant containing an N group, and (2) a surfactant, or a surfactant and a chelating agent as effective components.
An adsorption preventive method capable of preventing metal particles or metal compound particles in a colloid solution containing metal particles or metal compound particles from being absorbed on a porous membrane of synthetic polymer, in which the colloid solution contains (1) a water-soluble high molecular weight dispersant containing an N group, and (2) a chelating agent as effective components, provided that the colloid solution does not contain a surfactant.
The adsorption preventive method according to claim 14, wherein the porous membrane of synthetic polymer comprises a thermoplastic polymer of which the surface is hydrophilized, and the thermoplastic polymer is polyvinylidene fluoride or polyether sulfone.
An integrity test method of a virus removal membrane comprising
- causing a colloid solution of metal particles or metal compound particles to be filtered through the virus removal membrane which was used for virus removal, in which the colloid solution contains at least
- (1) metal particles or metal compound particles having an average particle diameter of 1-100 nm,
- (2) a water-soluble high molecular weight dispersant containing an N group, and
- (3) water and/or a water-soluble organic solvent, and has the following properties (a) and (b):
- (a) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range from pH4 to pH11 and
- (b) exhibiting a change in the maximum absorption wavelength in the range from −2.0 nm to +2.0 nm before and after being stored at 50° C. for one year at pH5.
An integrity test method of a virus removal membrane comprising
- causing a colloid solution of metal particles or metal compound particles with an average particle diameter of 1 to 100 nm to be filtered through the virus removal membrane which is a cellulose-type porous membrane and has been used for virus removal,
- in which the colloid solution contains at least
- (1) a water-soluble high molecular weight dispersant containing an N group, and
- (2) a surfactant, or a surfactant and a chelating agent as effective components.
An integrity test method of a virus removal membrane comprising
- causing a colloid solution of metal particles or metal compound particles with an average particle diameter of 1 to 100 nm to be filtered through the virus removal membrane which is a synthetic polymer porous membrane comprising a thermoplastic polymer of which the surface is hydrophilized and used for virus removal,
- in which the colloid solution contains at least
- (1) a water-soluble high molecular weight dispersant containing an N group, and
- (2) a chelating agent as effective components, provided that the colloid solution does not contain a surfactant.
Dependencies are inferred from the claim text.