Treatment or prevention of cancer and precancerous disorders
AssigneeFlorida Atlantic University
InventorsHerbert Weissbach, Lionel Resnick, David Binninger
Life of this patent
Estimating the term…
Abstract
The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
Claims46
A pharmaceutical composition comprising:
- sulindac, sulindac metabolites, sulindac derivatives and an oxidating agent.
A topical pharmaceutical composition comprising a sulindac gel and an oxidizing agent.
A method of treating an abnormal cell, said method comprising administering to an abnormal cell a pharmaceutical composition comprising sulindac, or sulindac metabolites, or sulindac derivatives or combinations thereof, and an oxidating agent, thereby treating an abnormal cell.
A method of treating cancer, said method comprising administering to a cancer cell a pharmaceutical composition comprising sulindac, or sulindac metabolites, or sulindac derivatives or combinations thereof, and an oxidating agent, thereby treating cancer.
Dependencies are inferred from the claim text.