Diamino-functional chalcones

A compound of the general formula

• (Y1)m—Ar1(X1)—C(═O)VAr2(X2)—(Y2)p
• and salts thereof,
• wherein Ar1 and Ar2 independently are selected from aryl and heteroaryl;
• V designates —CH2—CH2—, —CH═CH— or —C≡C—;
• m is a whole number selected from the group consisting of 0, 1, and 2,
• p is a whole number selected from the group consisting of 0, 1, and 2,
• wherein the sum of m and p is at least 1;
• each Y1 independently represents a diamino-functional substituent of the formula
• —NR3-Z-N(R1)R2,
• each Y2 independently represents a diamino-functional substituent of the formula
• —NR3-Z-N(R1)R2,
• wherein Z is a biradical —(C(RH)2)n—, wherein n is an integer in the range of 1-6 and each RH is independently selected from hydrogen and C1-6-alkyl, or wherein (RH)2 is ═O;
• R1 and R2 independently are selected from the group consisting of hydrogen, optionally substituted C1-12-alkyl, optionally substituted C2-12-alkenyl, optionally substituted C4-12-alkadienyl, optionally substituted C6-12-alkatrienyl, optionally substituted C2-12-alkynyl, optionally substituted C1-12-alkoxycarbonyl, optionally substituted C1-12-alkylcarbonyl, optionally substituted aryl, optionally substituted aryloxycarbonyl, optionally substituted arylcarbonyl, optionally substituted heteroaryl, optionally substituted heteroaryloxycarbonyl, optionally substituted heteroarylcarbonyl, aminocarbonyl, mono- and di(C1-6-alkyl)aminocarbonyl, amino-C1-6-alkyl-aminocarbonyl, mono- and di(C1-6-alkyl)amino-C1-6-alkyl-aminocarbonyl;
• wherein N(R1)R2) forms an optionally substituted nitrogen-containing heterocyclic ring;
• R3 is selected from hydrogen, C1-6-alkyl, and C1-6-alkylcarbonyl, said alkyl and alkylcarbonyl optionally carrying substituent(s) selected from halogen, hydroxy, C1-6-alkoxy, carboxy, C1-6-alkoxycarbonyl, C1-6-alkylcarbonyl, amino, mono- and di(C1-6-alkyl)amino, and aryl optionally substituted 1-3 times with C1-4-alkyl, C1-4-alkoxy, nitro, cyano, amino or halogen;
• or R1 and R3 together form a biradical Z which is as defined for Z;
• X1 and X2 independently designates a substituent present 0-5 times, on Ar1 and Ar2, respectively, wherein each X1 and X2 is independently selected from the group consisting of optionally substituted C1-12-alkyl, optionally substituted C2-12-alkenyl, optionally substituted C4-12-alkadienyl, optionally substituted C6-12-alkatrienyl, optionally substituted C2-12-alkynyl, hydroxy, optionally substituted C1-12-alkoxy, optionally substituted C2-12-alkenyloxy, carboxy, optionally substituted C1-12-alkoxycarbonyl, optionally substituted C1-12-alkylcarbonyl, formyl, C1-6-alkylsulphonylamino, optionally substituted aryl, optionally substituted aryloxycarbonyl, optionally substituted aryloxy, optionally substituted arylcarbonyl, optionally substituted arylamino, arylsulphonylamino, optionally substituted heteroaryl, optionally substituted heteroaryloxycarbonyl, optionally substituted heteroaryloxy, optionally substituted heteroarylcarbonyl, optionally substituted heteroarylamino, heteroarylsulphonylamino, optionally substituted heterocyclyl, optionally substituted heterocyclyloxycarbonyl, optionally substituted heterocyclyloxy, optionally substituted heterocyclylcarbonyl, optionally substituted heterocyclylamino, heterocyclylsulphonylamino, amino, mono- and di(C1-6-alkyl)amino, carbamoyl, mono- and di(C1-6-alkyl)aminocarbonyl, amino-C1-6-alkyl-aminocarbonyl, mono- and di(C1-6-alkyl)amino-C1-6-alkyl-aminocarbonyl, C1-6-alkylcarbonylamino, amino-C1-6-alkyl-carbonylamino, mono- and di(C1-6-alkyl)amino-C1-6-alkyl-carbonylamino, cyano, guanidino, carbamido, C1-6-alkanoyloxy, C1-6-alkylsulphonyl, C1-6-alkylsulphinyl, C1-6-alkylsulphonyloxy, aminosulfonyl, mono- and di(C1-6-alkyl)aminosulfonyl, nitro, optionally substituted C1-6-alkylthio, and halogen, where any nitrogen-bound C1-6-alkyl is optionally substituted with hydroxy, C1-6-alkoxy, C2-6-alkenyloxy, amino, mono- and di(C1-6-alkyl)amino, carboxy, C1-6-alkylcarbonylamino, halogen, C1-6-alkylthio, C1-6-alkyl-sulphonyl-amino, or guanidine.