Potassium channel opener
AssigneeMitsubishi Tanabe Pharma Corporation
InventorsYuji Imaizumi, Tomohiko Ohwada
Life of this patent
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Abstract
A potassium channel opener including a compound (e.g., pimaric acid) represented by the formula [I]: wherein R1, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4 and R5 may be bonded to each other to form a ring; or R6 and R7 may be bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.
Claims11
A method of opening potassium channels, which comprises administering an effective amount of a compound represented by the formula [I]:
- wherein R1, R2, R3, R4, R5, R6 and R7 are each independently a hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde or nitrile;
- or R4 and R5 are bonded to each other to form a ring;
- or R6 and R7 are bonded to each other to form a ring;
- and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds,
- or a physiologically acceptable salt thereof, to a mammal in need thereof.
A method of opening potassium channels which comprises administering a compound represented by the following formula (II):
- wherein R11, R12, R13, R14, R15, R16, R17, R18, R19, R20 and R21 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde or nitrile;
- or R20 and R21 are bonded to each other to form oxo,
- or a physiologically acceptable salt thereof,
- to a mammal including a human in need thereof.
Dependencies are inferred from the claim text.