Compositions and methods for treating vascular, autoimmune, and inflammatory diseases
OwnerMichael Hayden, Noel Hallinventors
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Abstract
The disclosure provides methods and compositions for the treatment of vascular, autoimmune and inflammatory diseases using a combination of an inosine monophosphate dehydrogenase (IMPDH) inhibitor and a HMG CoA reductase inhibitor.
Claims37
A method for treating a vascular, autoimmune, and/or inflammatory disease, or a condition associated therewith, comprising adjunctively administering to a human subject an amount of an IMPDH inhibitor and a HMG-CoA reductase inhibitor that is effective to treat or reduce the risk of the vascular, autoimmune and/or inflammatory disorder or the condition associated therewith.
A pharmaceutical composition comprising an IMPDH inhibitor and a HMG-CoA reductase inhibitor.
A stent coated with a composition comprising an IMPDH inhibitor and an HMG-CoA reductase inhibitor.
A method of preventing restenosis comprising administering to a subject an IMPDH inhibitor and an HMG-CoA reductase inhibitor.
A kit useful for treating a disease selected from among vascular, autoimmune and inflammatory disease, in a subject, the kit comprising:
- an effective amount of an IMPDH inhibitor;
- an effective amount of an HMG-CoA reductase inhibitor;
- and
- means for administering the IMPDH inhibitor and HMG-CoA reductase inhibitor in combination.
Dependencies are inferred from the claim text.