Substituted 5-membered ring compounds and their use

A compound of formula (I) or a salt, N-oxide, hydrate or solvate thereof, for use in human or veterinary medicine:

• wherein
• ring A is an aromatic or non-aromatic carbocyclic or heterocyclic ring having 5 ring atoms;
• R1 is attached to a first ring atom of ring A and is a group of formula (IA):
• -Ar1-(Alk1)p-(Z)r-(Alk2)s-Q (IA)
• wherein in any compatible combination
• Ar1 is an optionally substituted aryl or heteroaryl radical,
• Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals,
• p, r and s are independently 0 or 1,
• Z is —O—, —S—, —(C═O)—, —(C═S)—, —SO2—, —C(═O)O—, —C(═O)NRA—, —C(═S)NRA—, —SO2NRA—, —NRAC(═O)—, —NRASO2— or —NRA— wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical;
• R2 is attached to a second ring atom of ring A, which is adjacent the first ring atom to which R1 is attached, or is absent if that ring atom is a nitrogen atom which is double bonded to a neighboring ring atom, and if not absent R1 is hydrogen or
• (i) a group of formula (IA) as defined in relation to R1;
• (ii) a carboxamide radical;
• or
• (iii) a non aromatic carbocyclic or heterocyclic ring wherein a ring carbon is optionally substituted, and/or a ring nitrogen is optionally substituted by a group of formula -(Alk1)p-(Z)r(Alk2)s-Q wherein Q, Alk1, Alk2, Z, p, r and s are as defined above in relation to group (IA);
• and
• R3 is attached to a third ring atom of ring A, which is adjacent the second ring atom to which R2 is attached, or is absent if that ring atom is a nitrogen atom which is double bonded to a neighboring ring atom, and if not absent R2 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl;
• or a carboxyl, carboxamide or carboxyl ester group,
• PROVIDED THAT (a) at least one of R2 and R3 is present and is other than hydrogen and (b) the compound of formula (I) is not one of formula (IA) (IB), (IC) or (ID)
• wherein R1, R2 and R3 are as defined above, and R is hydrogen or optionally substituted C1-C6 alkyl.