Novel 3,4-disubstituted 1,2,3,6-tetrahydropyridine derivatives

A compound of formula I

• wherein
• X and W represent independently a nitrogen atom or a CH-group;
• V represents —(CH2)r—;
• -A-(CH2)s—;
• —CH2-A-(CH2)t;
• —(CH2)s-A-;
• —(CH2)2-A-(CH2)u—;
• -A-(CHF)v—B—;
• —CH2—CH2—CH2-A-CH2—;
• -A-CH2—CH2—B—CH2—;
• —CH2-A-CH2—CH—B—;
• —CH2—CH2—CH2-A-CH2—CH2—;
• —CH-2-CH2—CH2—C12-A-CH2—;
• -A-CH2—CH2—B—CH2—CH2—;
• —CH2-A-CH2—CH2—B—CH2—;
• —CH2-A-CH2—CH2—CH2—B—;
• or —CH2—CH2-A-CH2—CH2—B—;
• A and B independently represent —O—;
• —S—;
• —SO—;
• or —SO2—;
• U represents aryl;
• or heteroaryl;
• T represents —CONR1—;
• —(CFL)pOCO—;
• —(CH2)pN(R1)CO—;
• —(CH2)pN(R1)SO2—;
• —COO—;
• —(CH2)pOCONR1—;
• or —(CH2)pN(R1′)CONR1—;
• Q represents lower alkylene;
• or lower alkenylene;
• M represents hydrogen;
• cycloalkyl;
• aryl;
• heterocyclyl;
• heteroaryl;
• aryl-O(CH2)vR2;
• heteroaryl-O(CH2)vR2;
• aryl-O(CH2)2O(CH2)wR2;
• heteroaryl-(CH)2O(CH)wR2;
• aryl-OCH2CH(R5)CH2;
• or heteroaryl-OCHCH(R5)CH2R2;
• R1 and R1′ independently represent hydrogen;
• lower alkyl;
• lower alkenyl;
• lower alkinyl;
• cycloalkyl;
• aryl;
• or cycloalkyl-lower alkyl;
• R2 represents —OH, lower alkoxy, —OCOR3, —COOR3, —NR3R3, —OCONR3R3′, —NCONR3R3′, cyano, —CONR3R3′, SO3H, —SONR3R31, —CO-morpholin-4-yl, —CO-((4-loweralkyl)piperazin-1-yl), —NH(NH)NH2, or —NR4R4′, with the proviso that a carbon atom is attached at the most to one heteroatom in case this carbon atom is sp3-hybridized;
• R3 and R3′ independently represent hydrogen;
• lower alkyl;
• lower alkenyl;
• cycloalkyl;
• or cycloalkyl-lower alkyl;
• R4 and R4′ independently represent hydrogen;
• lower alkyl;
• cycloalkyl;
• cycloalkyl-lower alkyl;
• hydroxy-lower alkyl;
• —COOR2;
• or —CONe;
• R5 represents —OH, —OR2;
• —OCOR2;
• —OCOOR2;
• or R5 and R2 form together with the carbon atoms to which they are attached a 1,3-dioxolane ring which is substituted in position 2 with R3 and R3′;
• or R5 and R2 form together with the carbon atoms to which they are attached a 1,3-dioxolan-2-one ring;
• p is the integer 1, 2, 3 or 4;
• r is the integer 3, 4, 5, or 6;
• s is the integer 2, 3, 4 or 5;
• t is the integer 1, 2, 3 or 4;
• u is the integer 1, 2 or 3;
• v is the integer 2, 3 or 4;
• and
• w is the integer 1 or 2L
• or optically pure enantiomers, racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates, or the meso-form of the compound;
• or pharmaceutically acceptable salts, solvent complexes or morphological forms of the compound.