US 2006/0235055 A1 · Therapeutic agents useful for treating pain

Abstract

The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.

Claims27

Dependent claims

A compound of formula (I):

or a pharmaceutically acceptable salt thereof, wherein:
R1 is -halo, —CH3, —CF3, —NO2, —CN or —H;
Q is:
R3 and R4 are independently —CH2—, —CH(CH3)— or —C(O)—;
J is —N(H)— or —O—;
A is —C(O)— or —CH2—;
R2 is —(C1-C6)alkyl, —(C3-C8)cycloalkyl, -phenyl, -naphthyl, —(C14)aryl, -(5- to 10-membered)heteroaryl, -(3- to 7-membered)heterocycle or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R5 groups;
R5 is -halo, —(C1-C6)alkyl, —(C1-C6)alkoxy or —OC(halo)3;
a and b are independently 0, 1 or 2;
and
each halo is independently —F, —Cl, —Br or —I.

8 more elements

Dependencies are inferred from the claim text.

Therapeutic agents useful for treating pain

Life of this patent

Therapeutic agents useful for treating pain

Life of this patent

Abstract

Claims27