2-Thio-substituted imidazole derivatives and their use in pharmaceutics

A 2-thio-substituted imidazole derivative of the formula I:

• wherein
• R1 is C1-C6-alkyl, C3-C7-cycloalkyl or aryl which is unsubstituted or substituted by a halogen atom, by C1-C6-alkyl or by halo-C1-C6-alkyl;
• R2 is selected from the group consisting of:
• a) aryl-C1-C4-alkyl, where the aryl radical may have one, two or three substituents. independently of one another, selected from the group consisting of C1-C6-alkyl, C1-C6-alkoxy, halogen, C1-C6-alkylsulfanyl, C1C6-alkylsulfinyl, C1-C6-alkylsulfonyl and hydroxyl, and
• b) C1-C6-alkyl which is unsubstituted or substituted by CN or halogen,
• R3 is selected from the group consisting of
• a) NR4R10,
• b) NR7COR10,
• c) NR7COOR10,
• d) NR7CONR7R10,
• e) NR7CONR7COR10,
• f) OR10,
• g) S(O)mR10,
• h) halogen,
• i) OH,
• j) N3,
• k) NH2, and
• l) SH, and
• wherein R3 is not OH, halogen, C1-C6-alkylthio or C1-C6-alkoxy, if R2 is phenyl-C1-C4-alkyl, and the phenyl radical has a C1-C6-alkylsulfanyl, C1-C6-alkylsulfinyl or C1-C6-alkylsulfonyl substituent,
• R4 is H or a physiologically cleavable group,
• R5 and R6, which may be identical or different, are H, halogen, OH, C1-C6-alkoxy, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkylsulfanyl, NH2, C1-C6-alkylamino or di-C1-C6-alkylamino,
• R7 is R4, C1-C6-alkyl or benzyl,
• R10 is selected from the group consisting of:
• f) C1-C6-alkyl which is substituted by 2 or 3 phenyl groups, and
• g) trifluoromethyl,
• A is straight-chain or branched C1-C6-alkylene, C2-C6-alkenylene or C3-alkynylene,
• B is selected from the group consisting of:
• f) OC1-C6-alkyl,
• g) NR11R12,
• h) OH,
• i) halogen, and
• j) C1-C6-alkylsulfanyl,
• R11 and R12, which may be identical or different, are H, C1-C6-alkyl or phenyl,
• Hy is a 3- to 10-membered, non-aromatic mono-, bi- or tricyclic carbocycle, which may or may not be fused with a benzene ring,
• Ar is a 5- or 6-membered aromatic heterocycle, which has 1, 2 or 3 hetero-atoms, independently of one another, selected from the group consisting of O, S and N, and which may or may not be fused with a benzene ring,
• Het is a 5- or 6-membered, non-aromatic heterocycle, which has 1, 2 or 3 heteroatoms, independently of one another, selected from the group consisting of O, S and N, which may or may not be fused with a benzene ring, and which may or may not be bridged bicyclically or tricyclically;
• m is 0, 1, or 2;
• n is 1, 2, 3, 4 or 5;
• and the tautomers, optical isomers and physiologically acceptable salts thereof.