Diamine calcium channel blockers

A compound of the formula

• (Ar1—X1)n—NR1—X3—NR2—X2—CR3(Ar2)2 (1)
• and the salts and conjugates thereof, wherein
• each Ar1 is independently a cyclic moiety which is aromatic or nonaromatic, carbocyclic or heterocyclic wherein heterocyclic forms of Ar1 contain 1-3 heteroatoms selected from O, S and N;
• X1 is a linker comprising a chain of 1-5 members;
• n is 1 or 2;
• R1 is absent when n is 2 and when n is 1, R1 is H, alkyl (1-8C), alkenyl (2-8C) or alkynyl (2-8C);
• X3 is alkylene, alkenylene or alkynylene (2-8C);
• R2 is H, alkyl (1-8C), alkenyl (2-8C) or alkynyl (2-8C);
• X2 is a linker comprising a chain of 2-9 members;
• R3 is H, OH or alkyl (1-4C);
• each Ar2 independently comprises a 6-membered aromatic ring optionally containing 1-3 nitrogen atoms
• wherein each Ar1 and Ar2 in formula (1) may be unsubstituted or substituted by one or more substituents selected from the group consisting of ═O (in nonaromatic cyclic moieties), alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, alkylaryl, halo, CHF2, CF3, OCF3, OCHF2, CN, NO2, NR2, OR, SR, COR, COOR, CONR2, SOR, SO2R, SO3R, SONR2, SO2NR2, SO3NR2, NROCR, OOCR, NRSOR, NRSO2R, and NRSO3R, wherein R is H, alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, or alkylaryl or heteroforms of any of the foregoing, each of which may optionally be substituted, and wherein two R on the same N may form a 5-7 membered ring, and wherein two substituents on adjacent atoms may form a 5-7 membered ring;
• and
• wherein the chain comprised in X1 and X2 may be substituted by ═O, alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), halo, CHF2, CF3, OCF3, OCHF2, CN, NO2, NR2, OR, SR, COR, COOR, CONR2, SOR, SO2R, SO3R, SONR2, SO2NR2, SO3NR2, NROCR, OOCR, NRSOR, NRSO2R, and/or NRSO3R, wherein R is H or alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, or alkylaryl or heteroforms of any of the foregoing, each of which may optionally be substituted wherein two R on the same N may form a 5-7 membered ring, and wherein two substituents on adjacent atoms may form a 5-7 membered ring.