Non-imidazole aryloxyalkylamines

A compound of formula (I):

• wherein Ra and Rb are independently C1-8 alkyl, C3-8 alkenyl, C3-8 cycloalkyl,
• (C3-8 cycloalkyl) C1-6 alkyl, or taken together with the nitrogen to which they are attached form a 4-7 membered heterocyclyl optionally including up to 3 additional heteroatoms;
• n is 0-4;
• one of R1, R2, and R3 is G, and the remaining two are hydrogen or halo;
• G is a nitrogen-containing group selected from one of the following:
• —OL1Q, -L2Q, —N(L1Q)R5, -L3C(L1Q)R6R7, —C(L1Q)R6R7,
• wherein:
• L1 is C2-6 alkylene, C3-8 cycloalkylene, C4-6 alkenylene, C4-6 alkynylene, C2-5 alkanoyl, (phenyl)C1-6 alkylene, (naphthyl)C1-6 alkylene, (C2-5 heteroaryl)C1-6 alkylene, (phenoxy)C1-6 alkylene, or (C2-5 heteroaryloxy)C1-6 alkylene;
• L2 is C1-6 alkylene, C3-8 cycloalkylene, C3-6 alkenylene, C3-6 alkynylene, C2-5 alkanoyl, (phenyl)C1-6 alkylene, (naphthyl)C1-6 alkylene, (C1-5 heteroaryl)C1-6 alkylene, (phenoxy)C1-6 alkylene, (C1-5 heteroaryloxy)C1-6 alkylene, or (C1-5 heteroarylthio)C1-6 alkylene;
• L3 is C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C2-5 alkanoyl, (phenyl)C1-6 alkylene, phenyl, naphthyl, (naphthyl)C1-6 alkylene, C1-5 heteroaryl)C1-6 alkylene, (phenoxy)C1-6 alkylene, (C1-5 heteroaryloxy)C1-6 alkylene, or C2-5 heteroaryl;
• L4 is C1-5 alkylene;
• L5 is C1-5 alkylene;
• L6 is C1-5 alkylene;
• L7 is C1-5 alkylene or absent;
• Q is —NR8R9 or a non-aromatic C2-15 heterocyclyl ring system containing at least one nitrogen atom and optionally between 1 and 3 additional heteroatoms selected from O, S, and N in each ring;
• each of R5 and R6 is independently selected from hydrogen, C1-8 alkyl, C2-8 alkenyl, C3-7 cycloalkyl, (C3-7 cycloalkyl)C1-6 alkylene, C2-15 heterocycly and (C2-7 heterocyclyl)C1-6 alkylene;
• R7 is H, hydroxyl, halo, C2-6 alkoxy or absent where the carbon linking L6 and L7 (or bonded to R6) participates in a double bond;
• each of R8 and R9 is independently selected from hydrogen, C1-8 alkyl, C3-8 alkenyl, C3-7 cycloalkyl, (C3-7 cycloalkyl)C1-6 alkylene, C2-15 heterocyclyl, phenyl, (C2-15 heterocyclyl)C1-6 alkylene, and (phenyl) C1-6 alkylene;
• R10 is H, C1-8 alkyl, C3-8 alkenyl, C3-7 cycloalkyl, (C3-7 cycloalkyl)C1-6 alkylene, (C2-15 heterocyclyl)C1-6 alkylene, or (phenyl) C1-6 alkylene;
• wherein each of the above alkyl, alkylene, alkenyl, alkenylene, alkynyl, alkynylene, heterocyclyl, cycloalkyl, and aryl groups may each be independently and optionally substituted with between 1 and 3 substituents selected from halo, amino, nitro, hydroxyl, and C1-3 alkyl;
• wherein substituents of Q can be further selected from carboxamide, C2-6 alkyl, C1-8 heterocyclyl, N(C1-6 alkyl)(C1-8 heterocyclyl), NH(C1-8 heterocyclyl), (C1-8 heterocyclyl) C1-3 alkylene, O(C1-8 heterocyclyl), C1-6 alkoxy, (phenyl)C3-6 cycloalkyl-O—, phenyl, (phenyl) C1-3 alkylene, N(C1-6 alkyl)[(phenyl)C1-3 alkylene], and (phenyl)C1-3 alkylene-O— where each of above heterocyclyl, phenyl, and alkyl groups may be optionally substituted with from 1 to 3 substituents independently selected from halogen, nitro, cyano, and C1-3 alkyl;
• or a pharmaceutically acceptable salt, ester, or amide thereof, provided that when NRaRb is a six-membered heterocyclyl ring system and G is
• L3 is not phenyl or naphthyl