Azabicyclononene derivatives

Compounds of the general formula I

• wherein
• W is a six-membered, non benzofused, phenyl or heteroaryl ring, substituted by V in meta or para position;
• V represents a bond;
• —(CH2)r—;
• -A-(CH2)s—;
• —CH2-A-(CH2)t—;
• —(CH2)s-A-;
• —(CH2)2-A-(CH2)u—;
• -A-(CH2)v—B—;
• —CH2—CH2—CH2-A-CH2—;
• -A-CH2—CH2—B—CH2—;
• —CH2-A-CH2—CH2—B—;
• —CH2—CH2—CH2-A-CH2—CH2—;
• —CH2—CH2—CH2—CH2-A-CH2—;
• -A-CH2—CH2—B—CH2—CH2—;
• —CH2-A-CH2—CH2—B—CH2—;
• —CH2-A-CH2—CH2—CH2—B—;
• —CH2—CH2-A-CH2—CH2—B—;
• —O—CH2—CH(OCH3)—CH2—O—;
• —O—CH2—CH(CH3)—CH2—O—;
• —O—CH2—CH(CF3)—CH2—O—;
• —O—CH2—C(CH3)2—CH2—O—;
• —O—CH2—C(CH3)2—O—;
• —O—C(CH3)2—CH2—O—;
• —O—CH2—CH(CH3)—O—;
• —O—CH(CH3)—CH2—O—;
• —O—CH2—C(CH2CH2)—O—;
• or —O—C(CH2CH2)—CH2—O—;
• A and B independently represent —O—;
• —S—;
• —SO—;
• —SO2—;
• U represents aryl;
• heteroaryl;
• T represents —CONR1—;
• —(CH2)pOCO—;
• —(CH2)pN(R1)CO—;
• —(CH2)pN(R1)SO2—;
• or —COO—;
• Q represents lower alkylene;
• lower alkenylene;
• M represents hydrogen;
• cycloalkyl;
• aryl;
• heterocyclyl;
• heteroaryl;
• aryl-O(CH2)vR5—;
• heteroaryl-O(CH2)vR5—;
• aryl-O(CH2)2O(CH2)wR5—;
• heteroaryl-(CH2)2O(CH2)wR5—;
• L represents —H;
• —CH2OR3;
• —CH2NR2R3;
• —CH2NR2COR3;
• —CH2NR2SO2R3;
• —CO2R3;
• —CH2OCONR2R3;
• —CONR2R3;
• —CH2NR2CONR2R3;
• —CH2SO2NR2R3;
• —CH2SR3;
• —CH2SOR3;
• —CH2SO2R3;
• R1 represents hydrogen;
• lower alkyl;
• lower alkenyl;
• lower alkinyl;
• cycloalkyl;
• aryl;
• cycloalkyl -lower alkyl;
• R2 and R2′ independently represent hydrogen;
• lower alkyl;
• lower alkenyl;
• cycloalkyl;
• cycloalkyl -lower alkyl;
• R3 represents hydrogen;
• lower alkyl;
• lower alkenyl;
• cycloalkyl;
• aryl;
• heteroaryl;
• heterocyclyl;
• cycloalkyl-lower alkyl;
• aryl-lower alkyl;
• heteroaryl-lower alkyl;
• heterocyclyl-lower alkyl;
• aryloxy-lower alkyl;
• heteroaryloxy-lower alkyl, whereby these groups may be unsubstituted or mono-, di- or trisubstituted with hydroxy, —OCOR2, —COOR2, lower alkoxy, cyano, —CONR2R2′, —CO-morpholin-4-yl, —CO-((4-loweralkyl)piperazin-1-yl), —NH(NH)NH2, —NR4R4′ or lower alkyl, with the proviso that a carbon atom is attached at the most to one heteroatom in case this carbon atom is sp3-hybridized;
• R4 and R4′ independently represents hydrogen;
• lower alkyl;
• cycloalkyl;
• cycloalkyl-lower alkyl;
• hydroxy-lower alkyl;
• —COOR2;
• —CONH2;
• R5 represents —OH, —OCOR2, —COOR2, —NR2R2′, —OCONR2R2′, —NCONR2R2′, cyano, —CONR2R2′, SO3H, —SONR2R2′, —CO-morpholin-4-yl, —CO-((4-loweralkyl)piperazin-1-yl), —NH(NH)NH2, —NR4R4′, with the proviso that a carbon atom is attached at the most to one heteroatom in case this carbon atom is sp3-hybridized;
• p is the integer 1, 2, 3 or 4;
• r is the integer 3, 4, 5, or 6;
• s is the integer 2, 3, 4, or 5;
• t is the integer 1, 2, 3, or 4;
• u is the integer 1, 2, or 3;
• v is the integer 2, 3, or 4;
• w is the integer 1 or 2;
• and optically pure enantiomers, mixtures of enantiomers such as racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates, and the meso-form;
• as well as pharmaceutically acceptable salts, solvent complexes and morphological forms.